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04.09.30, ŦԼʱайĴ
04.09.30, ɽʿйʵӡ
04.09.30, ʿ֡ûʸ񵱱ڡ
04.09.30, ˹ˡѧѡεѡ֪ʶʮѡ
04.09.30, ƷצԶɽСǼС𣿡
04.09.30, coyotejoy췽ҹ̷棡HerceptinĹ¡
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04.09.30, ȫšʶŮ֮Ƹ桷
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顱ĻɡлѧʽϾٰġ
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ʽйյضԹа
ͳһ̻ᡱĹϵƾֿƺϷݣڹȥ
Уͳһ̻йĽ塣ֽŦԼʱפ
ɭ4ǰ׫дıȫķԱô˽
ͳһ̻նַ


йĴ

ŦԼʱ2000912
Elisabeth Rosenthal

911աһܲŦԼС
Եйı˼룺ǰΪǲµģ
ʵҪģǷֹ̲Ψһ

ͨṩѵۻ͹飬ʽѾһ
ЩصйԱӵһЩйԱǵĹ
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һо˺ϵ֮
Ѿÿһʡչڱİ칫Ҿ
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෽ᶼǹй
˶Ըڽ;˶رսһ
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ʽһλ˵ķʿġ
ϳʵͳһ̻Ĵʼˡܲͳһ
¥ϡ쵼˶ͳһ̻Ա

йԱǳأЩֻ֧Ĺ˲
̫֮ʲôйѧԺҽѧѧ
ר˵֯ƻйֹ̲Ŭ


֯˵й֧ߡ󲿷
ҳϵĹԱߡ΢֪һ
ڽ̸ͳһ̻ʲô˵Լ
16ʱҮʥ˵
ǽ̻ͽġ游ĸԸΪ
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Ĳ֧ౣصҵصĺͨ
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Ƕڽ̻ģԼҵͶʺ;ά֡
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һ˲ͳһ̻ͽSaunder
˵ڶ5000ѧУСʦͳһ
Ĺ۵㣬ǲ֧ڽ

й߿˵ǣö
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˵ѽΪĵй밬̲
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ݽϷϰȫֹܹСHIV
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HIVһʡһʡشйʱй˺
ʱڽһõµ̲Ӻ˵
ӺһHIVվ˺д
һݹڹʽйĹı棬Ϊ
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̻Ĺϵͳһ̻һֲӹ㷺ʷ
֯׮۸ӵ⣬ԼһЩǴͳڽ

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˵ͳһ̻ᣬ˵ǡˡ
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ǲǰһλ𾴵ڽ䡣

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ߡǽһͷ壬ṩǮ
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֯1990ھѾй˹ϵ
ʿ˵1994һй죬첩
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Bridgeportѧȥμһֻᣬѧͳһ̻ӵеġ
˵ġ֮һ˵й˲ܾܾ
Ļᡣ

ǲЩ˼룬Ҳ⿴ǵŮ
εĻᡣ˵

GopherŦԼʱ2000912գ

(XYS20040930) 

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ʿйʵ

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⣬ͬкܶ಻ʵйʿ
ȣҲѧԱعʵġ¼

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http://qdv.cn/view.aspx?Id=1462

˹͢ ˹Justin EvansѧԺѧԺܼ
ѵϯڣڶϷԺʵƸоԱ
Mystic Arts ˾ܼࡣ˹͢ ˹ҵŦԼѧӰѧ
ԺУڼɵĵӰƷѡɽɽʵӰᣬ־
ӰˡƪӰ˺󣬽˹͢ ˹Ŷɿƻ
龰ϲƬǽٳߡ(Noz & Grakk: Alien Abductors)
ӻƽʱβIFILM񶯻Ƭһ20038
ذǰʮ־Ӱˡרã־
˽˹͢ ˹ҵǣƷͬʱõȫĶ
˶̬վwww.animwatch.comĹע˹͢ ˹ǳɹ
Ӱʦҡҡ2003꣬˹͢ ˹ڱѵһй
ѧԱԱйıȡʵʽѧ顣

ᵽǽٳߣʵֻһеĵӶû
ӻƽʱβ

Ƕĵַhttp://www.nozandgrakk.com/

УΪֵӰݡֻԼ
֯һӶδӦùϺֵӰݵĳƺţ
Ϊûں浶ǹɹ

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ǸӰְSYSTEM SUPPORTҪְΪ
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йһġΪýߣشǰ棬
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ˡЩֻҪ˹վϾͿԲóSYSTEM SUPPORTصй
ͿԳư˹ôǷBLUE SKYɨҲ˵˹
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ڶҵԱ٣֪Ϊûָ˹ƺŵĲ֮
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ѧѡεѡ֪ʶʮѡ

ߣ˹

⼸ĲƽȻ³Ѹκһϸ϶޷
ᲢۣȴҲһͬ顣ʮ¼ɵɥԶ
һ¼ӰġӰĻһ
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ԣǴͨϰУǴ֪ʶУ
ڵ֪ʶУҴƱԵԡɡ
ȵƯʻװԡ֪ΪɫԡϡΪԡΪ
ԡ޶ȵ޲ƽȡΪռĿ֪ʶӵУⲻòҾ
һȦF4ĴϵͳСʮ󾯲족
ʮԱȫܹСʮͶģСʮܳꡱ
ϴѧʱѧУÿ궼ҪʮҵǸССĵλÿ궼
ʮȽߡ֪ʶ磨ʵйȻظʮ
󹫹֪ʶӡϣҴһȫ泬ԽеġN
ѡագ֪ʶӹȻڲͬ

˻ٳһ֤ѡĺԼνаصνЧ
ءΪݣѾڰĿϺָ
Ρʮѡ֮ѡᷴӳƫãȻ
ϣʮ󡱵ͬ߶޷ѡӹԷ͡ƵĻ
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ѡǡ޳ܡѡǡ֪ȡѡƭȺ
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ôеĶôϵı⣬ôеΣô
ҿ԰űȾһֱеͶƱѡʱλšʮȨ
ͬҲȵİɣҲͶƱĻҲЩΪ
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ڷɹ涨ġƶ޹֮УϿ㶯Ĵ
Ĵһ¼ʵʵ޴ҲӦýʵ̫
ˣ˶ʮһͣ˽죬ҾѡԴΪ
ѾʱΪרȨӦֲֵ
֯ʱͻȻͰԻڵһȺð
ƴ󣬸ݽ겣ñӺɣǡѡԺ壬һ
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֤Ψ̵ǣǱ仯ġҲ˵ʮǷʵ飬
ѡ߶Ƿˣ˾ͻ᷸˾˾вȷء
ʮ󡱣ǷҪǷҪÿһֻʮ
߼ְƺּЧЧЩͲ
ˣͲѧˣͲϡˣ˵
ѧȥΪԭѧɹ½ˣԽˣӰ
ˣܵˣǸǺãЩʮѹͣӰ
Ѿǹ׶ۣԺʿ֪ʶӡѧѾ
ˣ޻˵Щģѧвôģڼѧϰ
еģѧǡѧģôѡʮ󡱣
ʮéռסˡ°ɣȻѧɹΪ㣬
йӰΪ㣬ԡΪ㣬Һóѻƪѧ
˭ҲųN󾭹ŬΪӰйġ֪ʶ
ӡĿԣˣʱ˰λռסҸǺã

ũ޲Գɶ֪ĵǵġ֪ʶ
ӡΪʲô˼ɴҪԼǩѧѵǷһЩ
䡢֪ʶӡ ֮ѧѵд
һЩüǧ˻ĵ𣿡Ӱйô
ΰҵôĳҵȴ׵رãͻȻءء
εءǶ׵رãûһ㡰ɫʣȫڹ
ͻȻ֪СʮӰԼôƺǣô˼ǣѡӰ
ȫҲڴèһ˵ףһȺ֪ʶ
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ǡҺ㷽ҵǳǹ硱ⲻ֪־Ľ
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ĽѵΪͷԷȡǶôĻʢٺǣǶô
Цڵ֮ȻһԬһϵˡŷ޴Ȩ
źͿ½ųǵ֪ʶҪԼȨҪ
ױҪԼϵƷҪӴڣȲҪԼǩ
ҪʾԼڲͬǶôţǶôҪȨ
ǶôҪ׳ﷴԵһôٹ̣
ǷԵľҪȡġҴӡʮ־Ψһֵм
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˵һǧһ򣬲ȰĳЩһ䣺ѡN󣬲
ƷȻһ־磺ѡN󣬲Ʒ
ƽȲƽȣ֪Ӯ֪ѧѡԶѣ
ˣѧҵλʵҲ

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ԶɽСǼС

ߣƷצ

ϴαֳڸʷ࣬ʼԺǧ
һרߵͨ 
ϴαֳڸʷ࣬ʼԺı
׼й 
ÿһϴαֳڸʷйˣ
ʼʵĿ¡Ǳ׼ġйˡ 
    Զɽй塪񻯵ġ䡱Ϊ 

Զɽ2ֵƪġй 

ԶɽСǼС 

й֪ʶȻصġй֪Σ
ôйǵġ븻ǿ 

ǿסģ49ǰһׯϳŵȽɵ
ŵһ֡ƫƫɵţƷ˵ʱ񵳵ר
ׯϵĳŵȻڼʮΪԡйʽͷ
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֪ʶӣȻΪ˶Զɽչ̰ʽ
ing,ˡй˾Ȼĵˮ׼

(XYS20040930)

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췽ҹ̷棡HerceptinĹ

coyotejoy

̸ɫ䣬ǷʮʲôǰŴ䣬ѧƷͲ
방֢ķأȻ԰֢ȫ̵ʶʼDNA
ȷͻķ֮1976꣬ݴѧɽɽУ(UCSF)Ĳѧ
˶Ф(Michael Bishop) Ĳʿ޶¡ֶķ˹(Harold 
Varmus)˹ڷֵһ°(oncogenes)ģ֤˰֢ĸԴ
ϸĻ֮УЩ״̬¶ϸΪҪܣȻ
֢пͨŴһĵ°֢Ļ򣬵
£ϸЩصӰӶ֢
ǵķ׼ȷϸز˰֢ıʣͬʱ1989ŵҽ
ѧ

1984꣬Ӣ׻ѧˡطƶ(Mike Waterfield) 
˾(Genentech)Ļ¡רҰڶ(Axel Ullrich) 
ɫеרԼɪϯ˹(Joseph Schlessinger)ּϵ°
ERB-Bɲϸź(Epidermal Growth Factor ReceptorEGFR)
ĻɣֱڼϵĳѪһֽϸź
֢оϵ״ν°ûơ£ϸ
ϸͷѣһ죬ϸ޿Ƶ°֢е
ɵϸͷѵĻɡʮһֳ
ʶд˸е̿顣

ʮһϵ°򱻼ͷ֣ϸڴ
Ϣִйܵоչѧǻ방֢صְ
(tumor suppressor genes)ȶԻ(stability genes)˽
°Ͻס˵ļ˾ţȻֱǰ
ְñϵĳբʧ飬˾ͣҲͣסȱݵȶ
ԻñȲеʦά޲ܲܣͣͣ
Щϡӵر˴˹¸ʹİ֢ڵ
ڶĸϸҲӦİ汾ɼЩѾ˳
ǧ꣬ΪϸִһЩҪܣĽȻѡ
Ҳ޷ǰ֢ԴҲṩư֢ϣ

ʮֵĿ¡ҲƼҵУ1976
Genentechҵȷ棬һڵʱͬڿѧ񻰵ļ
ϣͨӵϸ嵰ףѧǽϳDNAԴ
DNAϸУʶŴ룬ҩõס1983꣬ڶ¡
EGFR򣬽֮ΪHER-2(human epidermal growth factor 
receptor-2)ĵסʱҲERB-B-2Ϊ
ͬ汾ERB-B°ʵ1979ͱʡѧԺ
(MIT) ޲ءΤ(Robert Weinberg) 쵼Сͨͬо
ֲΪNEUȻʱΤоȤע
һ°RASϣû̫עͼNEU䵰׵о
µĻƪʧۣ֮Τһȡõ
ɾҲЦHER-2ҲΪHER-2/NEU

HER-2/NEUĵʹϸɰϸһ
ı¶ԦǷֺͿ¡ҩHerceptin
ĺĲ֣ǶʮͺҶѧ방֢ĽȡõıȽڽ׶εһ
Ҫʤ

1986괺,ڵڶԼݴѧɼУ(UCLA)ĵ
˹˹(Dennis Slamon) һϯ̸ƿµҪһҳ
ʱԵо൱Ͷ˹һλ
רңһĸ𾴵ҽڰ֢о
ٴơռƬð֢ԴܼС
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ռƬȡDNAжաHER-2/NEUĳ
ѳϵƬУHER-2/NEU쳣ߺEGFR嵰
סһֺᴩϸĤҰἤøϸ岿ֱ
źŴϸϸͷѵĻHER-2
죬嵰׹ȱϸյźŹأƣ֢
ϸԼHER-2/NEU壬ʹ
һ֮䡣о֣HER-2ȱٰߴ
ԼռٰȺİٷ֮ʮٷ֮ʮ

ڶ˹ĹǿķǶô
Ϊڶܹ˴Լһʮ°Ļ˹
ռĸϸDNAգHER-2ΪѳԷۣ
˹оٰϡͨоٰ߲ʷ
HER-2ȱٰ׸ɢ졣ⷢʵҲṩ
һ׼ȷɿİ֢ϹߡǵĹ1987Ԫºŵġѧ
ڿϣ˲ٰԼٰоеһشչ

ֽ񹲷ֵĴԼһһʮְ֢УٰŮкܳһְ֢
Ϊٷ֮˵ٷ֮šÿߴʮ򣬴Լ
ΪǧȫΧڣÿӽʮ򡣶
ڵֻͨ׿Ĵʵ֣Ʒг䣬
ƣɶƷʮ͵ʮͰʮٰķһ
ֱû̫仯û̫չڷ׿󣬽л
֯Ƭ飬Ƕ鷿гЩ󻹸Իѧ
Ʒֹɢ򸴷ȫȥϸͻ
֯ɶɶĳЩٰЧѪҺյĸ
ãԻƱȽãҲֻǱȱ׼Ʒöѡٰ
Ԥ⣬ʱֻһ׿飬ʱһССûȥ
ʱѾɢû֪֢δɢܰͽᣬĿ
Сٷ֮ʮĸŮ״εƺûиһ


ڶ˹˷HER-2/neuٰչеĹؼã
û漰ٰϢͨϸ嵰ʹڳΪĳ
ƷİбꡣǽһоùHER-2/NEUҺ
пɽϸתɰϸĳַ򡰹رաϸ
ϸGENENTECH߲ŵоǿʼһHER-2/NEU
ĵ¡(monoclonal antibody, MAb)ڽϸڲĵֿ
ֵϸͲһֵףϸ򲡶ĳַרŽϡ
ָߣаƵĲͬ塣¡ʵ
ĳһĵͬǾȷͬİбꡣоõĵ
¡ܹرٰϸйHER-2/NEUףʹðϸֹͣ
ͷѣϸûӰ졣ߣϸֻظˡ
һأHER-2/NEUרŵİбӰ콡֯

˹ֲйȱHER-2/NEUģϲ˿
ЧԣԲǹȱHER-2/NEUĻٰû
áооҲṩ˸֧ݡ1988꣬˹
ڶȻȷоһٰĺǰƷˡȻ
ʱGENENTECHľӪԲûڻоİ֢ƷҪг̫
ԸⷽðͶʡڶеɥӹ˾ְŻ
˾ְּĳѧĽڡ

GENENTECH֮ĹϮ˲һ̽ѧԺ
ȻܿǷҩ￪ǳ˵Ľһҩʵһģ
϶ôϣձ뾭Ǯʱٴʵɳ
ʽĳܵĿ顣ĳҩٴʵһжпܽһ˾
ᣬʹù˾һĹ켣̻꣬߾Ǽ򵥵
׵յ˷ǧԪʽGENENTECHڿѧо棬һֱܳ㣬
ҩ￪⾭Ӫ߹һ۵Ĺ̡ʮ˾ڿ
(interferon)ʱȽȹĴ˰֢ȫǣٴʵ
ȴָô£˾ڵǮʧȥ˹ڵΡ
GENENTECH֮ɢٴоţ԰֢оٸȤ˾Ҫ
ӯA?tivase(t-PA) (human growth factor)

ڶ֮ˡл(Mike Shepard) HER-2/NEUĿ
ΪĿһȷ֢ķˮƽϵĻȷ
;мǿһеƷġֲи
ͼ˵ײ㵫δ˹ҲƵɧšGENENTECHϲԱ
ͼŷҪͰĿ˹HER-2Ŀ
ŽڽƵĿȣGENENTECHʩѹüµĹš
ûӵȨûǮֲôӰ죬HER-2
ڵоͶ͹࣬ԼҲûҩHER-2Ŀ
Ƕһְض࣬ɫչһϢ

лº˹оõһĵ¡壬Դ׿
߷ӦַӦʹӾ硣
״ݻٰϸ֮ǰȱϵͳݻٵˣżأϵͳ
ĹӦΣ˵ÿư֢һϵ
һϮĳضİϸϵķӰб곣ʧˣ
֢ȻʧȥƵط賤˾õ¡ư֢ĳҲ
սŰܣ޹ֺGENENTECHĹHER-2Ŀ֮Աǣ֮Ϊ췽ҹ̷
֮١1989УHER-2ĿѾصˡʱһڶ
;߽ײĹؼĸױϵתٰʼע
Ʒо״˽⵽HER-2Ŀ֧ĿĿѧվ
һڽĿƵٴʵĽ׶Ρ

ʱµļչʹGENENTECHԿ˷ԴԿľ޺Ͷ̴
ޡ(Paul Carter)ҵһֽԴԿԴķ
(humanized monoclonal antibodies)ñȸƤαװǷ
Խ󵰰ױͬ൰׵İ汾ӶԴԵ׿
߷ӦǱȽϴĵףɻָϳɣ
Я󵥿¡жӦУµĻ
ָϳɳһµԴĵףбϵĹؼֱֲ,Ȼ
о֤ԴĵȻ방ϸHER-2ӽϣ
߷Ӧڵİ˥Ҳˡ

ҲڴʱGENENTECHȻ˾ڳ
ʽȱ˾ɷݵİٷ֮ʮԶʮһʿϹ˾
(Hoffmann-La Roche)ϵĹHER-2ĿȤֿʼ
Ŀʽ˵GENENTECHȻͦĿһ
ԴԿãһȴƱԴHER-2塣
󣬹ͺӵȶģϲԴûʾԣ1990괺쿪
ʼԴãʵʹעһĿҲܶԲ
áƱԴŬʮҲ˺ܴɹͽչ
ʵ鷢ԴԴбϸڶģϵĲû
Դжԡ

GENENTECHٰҽƽȨ?ŵ(Larry Norton)ٴʵ
ѡٴʵƺоû˹ٴʵое
Ρ˹һԣҵλԺյĲ˼ڶĸм
ױƷ˾Revlonһʮľ޶Լͨʢ
ĴȼóıԼʮ𡣴1989굽1997ףRevlon
UCLAĸŮ֢оͶһǧٶԪ˹Բͷ
оNational Institute of HealthNIH޵оʽ𣬿
ԸͶһֱHER-2оˡЩʽԮGENENTECH
HERCEPTINĿУ˺Ҫá˹Ǯٴо
ͬʱҲʼһ뻯ԼCisplatinۺʹ
ٰ뷨ҩĳЩһĽͬʱ
ϸϵźʱԼиõĻɱϸۺ
ܻЭͬЧ(synergistic effects) 

ڵһڵİȫУ15תHER-2/NEUԵٰŮ
˻ĵ¡Cisplatinơڰ֢ٴʵУԷӦı
׼ֶ׿С50%׼ٴʵĳɹ
Ϊٷ֮ʮڶڹЧԵٴʵУ431˱ȫ
ˡԴ弴ʹڷļעҲû߷ӦҲûʹ
İбHER-2/NEUʧķ֮һĲ˵СˡĲ˵
ûҲûСٰ߶ԣһԵķӦˡ
Ϊʹ֢ܽԼҲһѡ

1995ٴʵ鿪ʼٴʵģϴ󣬻Ѹ߰
ӷּҪFDA˵Ҫݡʵ
Уһ469ʹù׼ƷĲˣһ234ʧܵĲ
ˣһ235ϵҲԸʹûƷתٰߡٴʵ
֣ƽԣHERCEPTINӳĸµʰ
֮ʮٷ֮˵˱ٷ֮ʮߵЧӦʵϿܿ
иõݡȱEGFRԹٵת¼
HER-2/NEUŴ󣬺߿FISH(fluorescence in situ hybridization)
⡣HERCEPTINֻϽƻŴϸȻļ
ʱδǵĲϸĻ֣ԱȻЩ˶û
ӦڵٴʵУоǻ˶ԿЧһµжϱ׼
֢ʱЧ(time to progression) ָƿʼת԰֢ɢ֮
һʱ䡣ʹ˿ĸŮܿʱƽԳδʹÿ
ĸŮô֤ӳٻֹ˰֢

ԷHERCEPTINTAXOLһЩҩۺƷҲȵʹ
򵥶ʹûҩЧHER-2/NEU岻ǶÿһHER-2Ե
õһԭһֲ˵İתƵ˴ԣHERCEPTIN
ĵ׷ӺٿܴѪ-(blood-brain barrier, BBB)Զ
Եİϸ޲ߡҲȫûиã40%Ĳڵ
һעʱзȺ֢״뻯ҩAdriamycinۺʹʱ
ʹͨ๦˥ߵĻҩһøӶ񻯡
HERCEPTINľҩ๤ϸ˹Ϊȼ򵥵
źŴҪӵöࡣ

ʵGENENTECHFDAݽҩĿ룬ϣҩ
ڵݽ׼1998925HERCEPTIN׼Ϊת
ٰҩСHERCEPTINУǴ˸˹
ִڿGENENTECH˾ֶһʱ

ڿѧϣHerceptinǶƷ(target therapy) ɹһ֤
ֵ춨ڻоϵƷֻаϸʧ֯
СԴͳĻƷһָԵͻơӸٴĳɹȻ߹
һ۵·֤Իҩһҩ﷢ֺͿ
;ҩ˾ϢʶۻռHerceptin
EGFR׼øһּøƼ(protein kinase inhibitorPKI)
֢һ֧׾ǼøHerceptin֮󣬼øƼ
ҩӿ֣¡ҩAvastin, ErbituxСҩѾ
ǵGleevecеIressaTarcevaPKIдʵ鷢ֺ
׶ΣڸıŰ֢Ƶںδ

Herceptinһֵ¡ҩԴ׵Դּϵĳ
ʹõ¡Ҳư֢ƹ˾һشף
ǽ췽ҹ̷Ƶ񻰱˴ֿɼʵ2003꣬Abbott/Cambridge 
Antibody TechnologyĵһȫԴĵ¡HumiraУ
¡Ʒһµ̱¡ҩƷгǰ＼
ҩƷĿǰٴʵĸ൥¡Լ100ռ
Ƶ＼ҩƷĿķ֮һ2003꣬ȫ򵥿¡гﵽ
ʮԪһ԰ٷ֮ʮǣЩ
ѧоҵֵʵ֣

HerceptinǶеٰ߶ЧֻԼغε
HER-2/NEUȱٰãЩȺռٰߵĴԼٷ
֮ʮٷ֮ʮÿԼٰ˿ҩ
2002Ϲ˾HerceptinȫУĲ˿
ҩȻĲҪרŵĻֶ(Genetic HercepTest)
ǵļڻŴHER-2ԡHerceptinǵһ
ϲҩƽṩƷĳҩֻض
ضȺЧڸ廯ƷHerceptinҩ
Ǹ廯(pharmacogenetics)ʱһ

: 
1.´󲿷ںժ޲ء(Robert Bazell)
Her 2The Making of Herceptin, a Revolutionary Treatment for Breast 
CancerReference 1Ȿϸʵ˷ֺͿHerceptinı͹
̣䱳͹̱κ֪Ϸ绹Ҫ۸Ӻ;ʷ׳ʡֵһ
гдѧּԭ˾ĹѧҵԸ
ƪд˲˼Լʹֳ
ǻֹۣۣΡЩĻ߲ĳҩƷߣ
еͳ֣ϵĸ壬ҲǿѧʵĻߺͿѧ
ֵĴٽˡ
2. ԼøƼҩо뿪ȤĶߣɽ롰֢
Ʒƪ¡GLEEVECĹ¡Ķwww.xys.org June 32004

References:

1.	Bazell, R. Her 2The Making of Herceptin, a Revolutionary 
Treatment for Breast CancerRandom House/New York, 1998
2.	Vogelstein, B., Kinzler, K.Cancer genes and the pathways 
they control Nature Medicine, Vol.10, 8, 2004, 789-799
3.	www.biox.cn/content/infoview/20040823441.htm ȫҽҩ
ҵعչ
4.	www.biox.cn/content/infoview/20040908734.htm ＼
ҵϲðղͶʡ
5.	Preziosi, P. Science, pharmacoeconomics and ethics in drug 
R&D: a sustainable future scenario? Nature Reviews Drug Discovery, 
Vol.3, 6, 2004, 521-526
6.	Lewis, R. Herceptin Earns Recognition in Breast Cancer 
ArsenalThe Scientist 15[9]:10, Apr. 30, 2001
7. www.researchandmarkets.com/reports/c2904 Late Stage Protein 
Kinase Inhibitors, Monoclonal Antibody Therapeutics: Current 
Market Dynamics & Future Outlook 
8 Carter, P. Improving the Efficacy of Antibody-Based Cancer 
Therapies Nature Review, Cancer, Vol.1, 11, 2001, 118-129

(XYS20040930)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.freedns.us)

˵ķˮ



    ʷٷҡ˹дһڷˮ飬ҪΪ˵仰ˮ
֮ѧڡĿȫ顷йڡࡱֿࡢռȹ
һࡣ彲ǽլ֮լָĹլָң
ʱ豳֮֮ͣҲŵȶԴ
̵С

    ǣҪȷۡˮӦôͷ˵ҲǱʷٷ
˹ʷȻĹɺĹǲһġǵ
Ǹո˳Ȼɺ󣬾صȻ
ⷢӵĽǣš

    ˵ţ̾뵽ռʵڹŴռѧͬʱ
ԴģоҲԭʼڹ۲ȻܽصȻۡ
Ƿչͷֵˣһ淢չΪĿѧһչΪ
ɫɫڹŴγһСġѧʡ

    Ҷʵת籭һʼһʽ
ǾһǮң˫ӳȨ
ǮΪϵһĻռԶʱǮҲǽ
ңǱǡڳδȻɣΪƲԡսĳɰܡ
ʤҪռԭʼǮҡʱֿܣΪ
Ϊ˫һűʾͿԽռƵ
ʽͲˡַͣšַŵĻϣ˰ԡ
ԭʼصȻ฽ᣬͷֱ졢ء硢סˮɽ
Ϊ˽ǧ򻯵󣬰ƺ̫ˣ
ǾͷչʮԣˡסһŴõ飬
ȴΪŻ⡣

    ǳѶͯʶʶչĳ߶ȣܵķչҲ
οʼġǼʹõĶʮƼΪ
ļʮָɵģɵļ㹤ߡַ
Ȼвͬ䱾ԴָΣͨõǰ
룬⣬ʮλļҪ
ѧķչģһ֮ԲȱʮΣһΪʮ¡
ִŷޣЩƷʮλģ磱֧Ǧһ򣬶
һޣ֧ҵУֵͣģӢ
ģţ̣ţ֣ţΣͣԣףţ̣֣ţȾǡйУ
һĵȣ׼֣ɺ͵֧

ɣ         
               
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йһҹΪʮʱֱӡîʾ
һҹΪСʱСʱΪһ졣ҹʱ磱
ʱ

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󡱡ֱ硱ﺥһǲظʮ顣ҹ
գ꣬ǧǰѾʹõġ֧һֱ
õڣ磱ǹﺥ꣬ҪͷʼǼ
ˣǹδꡣʮλơ

    ʶȻ͸ȻĹвܽɡʲôɵģ
ǰʲôɱ仯ģⶼҪ˼⡣ϣѧΪ
ֱԭԪءˮͻ𹹳ɵģԪֱַʡɡ
ʪеӦ

    йʵܴѧ˵ڡ鷶˵У
һԻˮԻԻľԻԻˮԻ£ԻϣľԻֱ
ԻӸ뼼𣡣ֱ̣࣬ᣬӸʡ
ΪпˣӺڡ֣˵
ľˮԳɰʵܽұյȷ
ľ顣

    ʱΪҵۻǾϽֶ
Ȼʶɽȥ巽ϡУɫࡢ
ơࡢסڡǵԭǻԭǻɫϷ
ǺǺǰɳɫɭ֣ɫĴ󺣣
ڱɽ԰̳ϣꡪ꣩ǰλ
ɫļλڼԭ򣬴ڶ ζ
硢ϷϷ硢硢ڱα硣
ķϵɵʮ֣͹ԭʼġһͳۣǾǶ
ľࣻϷࣻ켺ƣף
ɹˮڡʱѵʱȻĸʶһˡ
ͬʱԴʵ;飬ִ˵ۣǾǣľ
𡢻𡢽ˮˮľľˮˮ˻𡢻˽𡢽
ľԿľԭʼıˮʶˮǡˮڡ
ˮ飬

    һѧ˵صʹۺȻ۵ıܽᣬӦǶ
Ȼʶߡǵ˺ѧ˵˸Ӧ޸ݵ
չӲ׵ֲɵ¹ϵϡ峣ʡ塢ǡ
ţ루šС࣬ȣ£òӡ˼
ԡʮФȡͬʱְռİԷλҲȥγ
һӶǣǿϵһУָһУǧΪй
ͳۣӶ谭ִƼйķչΪŵ۸ݡ
罫˵Фѧ˵ãͿԵó˵ıľȣٸ
ۣͿԺϻ顣ŮֱǽľͲܽ飬Ϊ
ҪľġֱˮľϺûΪľˮ೤ġ磬
ﶼΪУҩͰɫ࣬ԾС˷
ɫҩ˵ɫľľܿ˻ˡַˮ
˵˵̣Ϊǵľܿѧ
ⲻйͳĻֵ÷ľӦɡ

    ʷٷҡ˹˵ҡҵȶáԡλ
ΪʲôأԡİǬ죩ˮޣɽ
ף㣨磩루𣩡أң󣩣Ǭ˳ʱ
һܣǵзλϣñΪˮϷΪ𣬲ìܡ˹
˵̫ǲȷġ

    ڰԷλ⣬ȷС족ˣ͡족֮֡
˹ȻΪ족Ϊڡ족֮
ȡʵϣ족δѧҰԸװðȺ
ߵˡڵķˮܶģĳЩġѧߡ
족ˣԷλȥоκġײͬȺ
֪ơ

    ˹˷ˮọ̃ĵڶȦ
λջǡ̡ĴͳأȻԷλ
ĹƣһЩˮҲõԷλ˹
˵ҡҵȶԷλֻǡ԰Ʋ
á족Էλȥо

    ӵаϵγѲԭʼصȻˡԴע
ˡ˺һ˼ȫΪͳη˾
ɫҲ֮ɫΪ˵촹󣬰Ҳ뵱Ȼ΢
ľ΢ǣǣʵ۵Ȼ΢·ĵϴ
ǶΧ΢ǣǣתΪ˵⣬ͰѻƵ޷ֳ飬
ٲ٣ࣩϹȸĹ٣ٰࣩ׻٣
ף䣨٣ڣΪ֮˵ǲȷģͳΪ
ŴˮҪݡ

    кͰйĴͳĻȻѧ۵ĺģʷ
ҡ˹ԷˮоҪۺ¼µķˮʦ̵ֽģ
ʷܵ󵼡

    ڹŴӵĽͷλȷǽˮġڲɹ⣬
ɽԵסĺ磬ˮ֮衣Ҳ
ܽᡣֻǺˡˮȫΪȨŪͳĹߣ
رǡլ֮˵ǵصصķ⽨ţ޿ȡ֮ʵ
ǻĵһ¾ΪԼĹһλһ׷լˮĴ
ʫ

ˮ˵գָָָ
зأβ̡

    ойŴĻĪӢԼɪľйŴĿ
ѧеġǣѧͼѧѧѧ
ѧΪˮǣ  壨αѧδ

    ҹլ֮ӷءɽǣС
Ĺʱ֮˵˼ˡһ㶼ڹĹ
Աʷٷҡ˹ڡլȤ󣬶صǡҾӷ
ˮ͡ҵˮ

    ˵ˮйչģзλլ
ȿǼ硣뿪йˣҲͬˡ
ϰסķӦϳźá

    ʷٷҡ˹ڰãˮʦֽ̣ойˮ
䡰˵̡оĽˮӺͽ飬
˼رǾҲ֣вοֵƩ磬ŲŲҪ
ҵţӵĴͷϲҪװܣҲҪڶ氲ӣ
оźӡЩ鶼ǲģҪ÷ˮ͡ǰ
ӦӦʶα̸ˮǰҪڿ
ףۺУҪˮȫ˵Ӧ
㣬㣬㣬ļӦ۵ģǼӦǴƵġ
ƺȫҵ˱ʶĳһ㣬żĳ˽ֻ
ԼԼ

    ҵˮʷٷҡ˹оһӡΪ
ͣڷ濪ͣƻ˷ˮⷴǰҲҪ
һʵӣڱκ壬һ̨ţ
ꡱĳĵ㣬űʽҵ˵Ƿˮļռʱ
Ȼ죬õʧյ棬涼յһšҵ
ؼƷͷ̬ȣںˮйоϻƺò
ˡ

    ᣬϲסڸ¥ķУϲԼ
Ĵл԰ƺİѡլƣ˹˵ֻǡ
԰Ʋá족ԷλȥоȻˮʦǲʲô
족Էλ޴ȥָ԰ơӦоǡ԰ѧ
ǡˮй԰ģӢ԰ֽҲǶ
ɫġ

    ʷٷҡ˹дⲿ˼˴ӲͬĽǶ
áǰд˲ٹйͳĻԴϣܲʷٷҡ˹
˽֮㡣

           ڡѧۡ2004

(XYS20040930)

˿(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.freedns.us)

šʶŮ֮Ƹ

ȫ

ҹߡñ鷭ǡı    ĳĳĳļĳ
ĳĳǺܶĹ˴ˣBBSϷдֵӻ
ֵ£ܿͶ

Ϊ˴ʵֲ࣬ɷŹ˴ʵ飬
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Ϊңֻʶһƪ״׶һ
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ļ֮ߺͼЧ֮󣬳͸ɵǵĻܲ𣿳Ϊ
Աһܽʱ˵ĳ߼Ҹе־࣬Լ
ĳĳĳҲ̸һξΪʿĳĳĳڵһ
ְߵ˵ģĲʸΪԱġ

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©¼£199697꣬ڵĵλմѧҵҳһ
⣺εĹϵмһĳĳĳġҷ֣
֪ʶԸˣϾǲʿǣͨƪһɰ
һеϢ͸һɹζû¼ǿǣ
ƢԶԹΪԸ֪ĳĳĳǷǸĳĳ
ĳ,,˵ܿ,ѾǸڼļˣȻɢ
ŹζɼҵжϲԭֱΪӦߣĳĳ
ĳȡ֮˳һθԷ˸ΪåʦӣΪ
Ϊ°ѧʱ򣬿δӲ֤ģ
һ仰--ʶŮˡҼԱϴ˵Ȼ
šΪˣţԭ֪ʶ֮£
Ҫƾζ֮벻֡ζ϶ؽԹΪ
һ϶Ը˽оǣ֮ԤԵȷ֤
Ԩбδ֮湦Ѱ˵˶ź

Ȼѡ˲иζ׼˲ضעԼȣò
׼ԼζַߣȷԼ羻ˮɫᡣζ֮棬
ܱҹֲ֣дζĴʵ˴ѩμӸ߿п
СථüнƨģԷζ˼ľĶʦʴ
͸˵ˣǰĳλȰθĿʮƪʮ
׼Ĵ޲紦Ӱ崿Ҳ᲻һ˿ζ
ߣһеĳĳĳޱ͸дҲдζһƪд
Ȼζ̱ǣԱ亦òĳĳĳĸ߼Ҹе־
š

ȻԼ±򲻿ز¶ʧȴȽơ֮
ʶдó˱ǡ绨ĿŮСָŪ
Ĵ˺ֹܶ࣬ζ֮ѱΪʤ̭еĺߡж
˵о͸д֮䣬Ԩ֮С
ѽ˹ɢ£ϰֿɵãĳĳĳֶΪΨһϰ
˵˹ӱԹȻ򣬻ӱԹ£ӰŮ
Ĺܣһǻۡĳĳĳȴ벻Уһ֡һ


ڳΪ˲ŵľУζףζ˱ռš˵㲻
ƻ㣬񣬱׼޷磬ȴг߶ȡ˻ĳĳ
Ϊũϣûũ¹ʣȷ֮
֤˲ò޲ݣ֮ǶǺֵֶ֮ĿŶȣԷ
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