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(XYS20050912)

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XIAO CG J UROLOGY 1990 143 A356
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Title: A POSSIBLE NEW REFLEX PATHWAY FOR MICTURITION AFTER 
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Author(s): XIAO CG, GODEC CJ
Source: PARAPLEGIA 32 (5): 300-307 MAY 1994
Document Type: Article
Language: English
3

õԼãڶƪChangǶ
2003һƪ£J Urol, 170 : 1237-1241, 2003ʾɡ

1. Xiao CG, Du MX, Li B, et al.
An artificial somatic-autonomic reflex pathway procedure for 
bladder control in children with spina bifida
JOURNAL OF UROLOGY 173 (6): 2112-2116 JUN 2005
Times Cited: 0

2. Chang SM
Re: An artificial somatic-central nervous system-autonomic reflex 
pathway for controllable micturition after spinal cord injury: 
Preliminary results in 15 patients - C. G. Xiao, M.-X. Do, C. Dai, B. 
Li, V. W. Nitti and W. C. de groat - J Urol, 170 : 1237-1241, 2003
JOURNAL OF UROLOGY 171 (6): 2387-2388 Part 1 JUN 2004
Times Cited: 0

3. Xiao CG, Du MX, Dai CP, et al.
An artificial somatic-central nervous system-autonomic reflex 
pathway for controllable micturition after spinal cord injury: 
Preliminary results in 15 patients
JOURNAL OF UROLOGY 170 (4): 1237-1241 Part 1 OCT 2003

ƪ
Title: "Skin-CNS-bladder" reflex pathway for micturition after 
spinal cord injury and its underlying mechanisms
Author(s): Xiao CG, De Groat WC, Godec CJ, Dai CP, Xiao Q
Source: JOURNAL OF UROLOGY 162 (3): 936-942 Part 1, SEP 1999
Document Type: Article
Language: English
5Σ2ƪ

1. Xiao CG, Du MX, Li B, et al.
An artificial somatic-autonomic reflex pathway procedure for 
bladder control in children with spina bifida
JOURNAL OF UROLOGY 173 (6): 2112-2116 JUN 2005

2. Middleton JW, Keast JR
Artificial autonomic reflexes: using functional electrical 
stimulation to mimic bladder reflexes after injury or disease
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL 113 (1-2): 3-15 JUN 30 
2004

3. Chang SM
Re: An artificial somatic-central nervous system-autonomic reflex 
pathway for controllable micturition after spinal cord injury: 
Preliminary results in 15 patients - C. G. Xiao, M.-X. Do, C. Dai, B. 
Li, V. W. Nitti and W. C. de groat - J Urol, 170 : 1237-1241, 2003
JOURNAL OF UROLOGY 171 (6): 2387-2388 Part 1 JUN 2004

4. Xiao CG, Du MX, Dai CP, et al.
An artificial somatic-central nervous system-autonomic reflex 
pathway for controllable micturition after spinal cord injury: 
Preliminary results in 15 patients
JOURNAL OF UROLOGY 170 (4): 1237-1241 Part 1 OCT 2003

5. Chang SM, Hou CL
The frequency and efficacy of differential sacral roots 
innervation to bladder detrusor in Asian people
SPINAL CORD 38 (12): 773-773 DEC 2000

ƪ
Title: An artificial somatic-central nervous system-autonomic 
reflex pathway for controllable micturition after spinal cord injury: 
Preliminary results in 15 patients
Author(s): Xiao CG, Du MX, Dai CP, Li B, Nitti VW, de Groat WC
Source: JOURNAL OF UROLOGY 170 (4): 1237-1241 Part 1, OCT 2003
Document Type: Article
Language: English
3 һƪ

1. Joseph DB
Bladder rehabilitation in children with spina bifida: 
State-of-the-"art"
JOURNAL OF UROLOGY 173 (6): 1850-1851 JUN 2005

2. Xiao CG, Du MX, Li B, et al.
An artificial somatic-autonomic reflex pathway procedure for 
bladder control in children with spina bifida
JOURNAL OF UROLOGY 173 (6): 2112-2116 JUN 2005

3. Myckatyn TM, Mackinnon SE, McDonald JW
Stem cell transplantation and other novel techniques for promoting 
recovery from spinal cord injury
TRANSPLANT IMMUNOLOGY 12 (3-4): 343-358 APR 2004

һƪ
Xiao CG, Du MX, Li B, Liu Z, Chen M, Chen ZH, Cheng P, Xue XN, 
Shapiro E, Lepor H. An artificial somatic-autonomic reflex pathway 
procedure for bladder control in children with spina bifida. J Urol. 
2005 Jun;173(6):2112-6.

2005.9.12 

(XYS20050912)

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Фȷͨ

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ά顣

йöԵĵط⻪Ӧ֧֣ûɻޡй
ϣй÷չȫйһ£ʹ뺣⻪˱޹أԻ
˵ĹҲǺ¡

ͬ۵ɱˣڲͬϣӦΪ˵Ϊй˵
Ӧֺ֧ЭйΪıΪ;ٴ롣Ȼڵйǹȥ
һٶȽϺõʱڣļйҲǹȥһٶȽ
õôûɲֻ֧Ϊйıȡ֯Ϊ

⻪ҲӦʼ𡰹Ժۺ֢ʱ

20059¡Ƽй

(XYS20050912)

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̴ҩƥףLipitorĹ

coyotejoy

˵ҩ˾뵽պպǵһƵ
ƷɫСҩƬΰ磨Viagraʵг۶ӮȽ
족Ϊ˹Դʹûͬ٭ٮȻ
1997ƳĽ̴Сҩƥסƥǵһ
ͻưڴصĳҩҲҩʷ۶ҩ2002
ȫʹ߼ߴǧİˡ

ƥأStatinҩеһҩﱻߵ̴Ѫ֢
ѪҺе̴͸ˮƽ̴ֹѪڱڳ
ӶԤӲѪܼз硣2002ƥ80
Ԫռҩгݶ46%һҩĬ˹˾
(Zocor)72Ԫռ33%ƥ׺ˣֱӵľ֣Ƕ
̳ϵԩҡ

ʮʮоѾѪҺеĵ̴󲿷ڸкϳɣ
Сʳաѧǻ˼ʮʱоõ
̴Ḷ́ɹذ쵨̴Ĺ̷ֽɶʮͬȻﻯ
ѧӦ˲ЩӦĶø߻ҩ
HMG-CoAԭø̴ϳ;ʼ֣ڼٵ̴Ĳ
ϸûɲʲʿ(Dr. Michael S. Brown) ͹˹¶ʿ(Dr. 
Joseph L. Goldstein) ֲͬ1985ŵҽѧ

оչĻϣҩĿͻоʼձ
1971꣬ձ(Sankyo)ҩ˾Զ(Akira Endo) ʿ쵼С
ɸѡǧֿȻHMG-CoAƼ΢մùз
벢(Mevastatin) ϵһ̴Ļ
ûճΪеҩ1978꣬ͨĺĬ˵ĿѧǼ
һ̴Ļ¦(Lovastatin)ٴʵ֮
1987꣬¦رFDA׼Ϊ̴ͬһҩƷ
(Mevacor)ʮУĬҲɳΪʱӯҩ﹫˾֮
һ

춷ҩƬ͵̴ӳǸ·
˵İȫЧҲĴɻĬһо֤ܼ
һЭԹڵĽʶѪ̴͸ߵಡ֮
Ľϵಡ˿ʼǵĵ̴ָʼѧŷ
áĸ֬׵̴(high-density lipoprotein cholesterolHDL-C)
͡ ĵ֬׵̴(low-density lipoprotein cholesterol, 
LDL-C)׷Ĭ˵ĳɹҩ￪Ƿӵг
BMS޷(Pravachol)ŵƳ˹(Lescol)

ԽԽĴǿʼصĴĬ¿ķ
(Simvastatin)19944£Ĭļ4Sٴʵо
4444йಡĸߵ̴ʹķ󣬲
̴35%ಡĿԼ42%FDAѸ׼ķ
Ϊ̱С˺ܿͷҩ1995꣬ͬʱ
Ϊ۶10ڵĳҩĬ˵ƺ˿Ƶ̴Ĵʡ

4SоٽҩۣҲƥ׵ĺճƽ˵·
ƥͬҩǸߣгʮꡣ
ɻ-ع˾(Warner-Lambert)Ĳ³˹˼(Bruce Ross)  
19858ºϳɣṹԶٵϳɵصĽṹơʱҩ
ģЧ˺ó٣ֻܳΪҩ
(Me-Too Drug) ѡȻһٴʵڵĶʵ
ص͹ƥ׵ҩЧõͼ10˼ɽ̴
38%ʹͬҩﾺFDAƼļ20˻Чʱ
زƷв֪ƥ׵Ĵڣ-ٴʵнȻ
ܵĲƷеҩܵıȽϲԡ1996괺죬ƥף
ˣˣ˹˺޷ҩｵ̴ЧԱȽϽ
ƥи͵Чʱƣƥ׽͵̴
Ч1997ԪFDA׼ͨƥʱ׼ƥһڵİȫЧ
1080ˣصļΧ2040ˡֵ͵ʼ
ͿļΧôͲ˶ܽܣȻFDA׼80ǰȫģ
ô10˿Ǿ԰ȫġƥױҩռ˸
ҵơ

-Щ֣Ϊг˾ҩ
Ĭ˵˾1996꣬óгӪĻҩ˾
ƥסгӪԱͨĵг춴ǵķϸ߻
󣬽һƥ׵ĿλΪԼ66𣬶ʱһµĻ
Ҫ120Ԫͼ۾ʹøĲѡƥסԴ෢
۹ơǳѵµһǧԱܵļѵ
ӽѧѧĿγѧϰټ֮ܵģۡ۴ʹһ
Աʽĳָơɼָԭôǰѻ
۴ɲҩ﹩Ӧ̣µõҩϢṩˡ˫
£1997괺ƥк󣬽˾Ĵ磬ܿߵ
ע˴Σ19986¼Ӯг18%ʱռг
37%֮2001Ʒгİλһͷ

1999ĩ-ͬⱻòƷ˾(American Home Products)
չ900ڵۺõ˻-أƥС
2001𣬻ֿʼ˶ߵֱӹЩһռ
ڶԵ̴ʶȻҪƹƥסȻֵۺ
ƱFDAơ200210£ȸǧŰƽظ
Ϊƥ״ҽƱ(MEDICAID)շѹĹ˾ͬ죬FDAûͣ
ֹǲ׼ȷƥ׿ûҩ֮õ־棬
޸Դǡ

ƥȻϣ۳ǣ統ĬһҲ
ٶսԽԽгܿ14˾2003
8£˹-ղῨ(AstraZeneca)˾ƳһΪ˼(Crestor) 
ҩƥҩЧߡ⣬ҩгչ
ͬʱ䳤ЧĹʵδʧ2001 ꣬ҮԸг
ҩﱴ(Baycol)ΪFDAΪ31ήµء
¼FDAҩϸ͵ء

Ȼ̴гȻԶδﱥڣгǰõòС
5ǧ2ߵ̴Ҫҩƣֻ֮һڷҩ
ͬҩѪܼҩܻӭġȫ
г2002188ڣ2007Ϊ236ڡóг
ƥ׵ר2009Żᵽڣ2005гۿﵽ150ڡ
˹2005Ԥ۽10ڣвƥ׵İλ

˵ר2005ʧЧĬ˵ӦԾӪжһ
תΪ̨ҩӢѾ2004׼תɹֱ̨ҩFDA
ô֮ǽ¿ĵ̴ҩγ
ҩС20047£Ĭ˺-(Schering-Plough) ˾ͬ
ά(Vytorin) FDA׼ͨСҩЧɷ֣Ƹ
е̴ĺϳɲһɷezetimibeֹСԵ̴աٴʵ
֤άȵһƥ׻˸Ч󣬽2006Ƴ
뵨̴תƵҩƷƷ͵֬
׵̴ˮƽɸƸ͸֬׵̴ˮƽ

оس˽͵̴;⣬кܶ
;ǱΪӮˡ˹ƥֵڶ ֻ
HMG-CoAԭøø춵̴ϳ;ʼ֣Ǹһб꣬
ȴԶЧ춵̴Ի
ɶɺάDǰ壬HMG-coAԭøӰ֧ϳɿø
QͨHMG-CoAԭøHMG-CoAԭø͵̴֮м仯
ﶼˣЩṩ˼õĻойо
ؿܿԱưȺĬ෢ӲƤͳմ֢ϵͳ
ϵо׿̱Ķ˶Լֹһ
̱оӰϵͳЧȫǽ̴Ч

ΪϵͳõͬһźŴ;Ҳϸãص
һ֮ܵǰ֢4Sооڰ֢ķս
ͣڶģϵʾغ̴
ҩĸŮٰ١ڵ̴Ͱ֢ϵо֮С
˼˾(Genaissance Pharm)оһ»ϲԷѰһ
־ЧƷϵʹ˽Ԥ
ЩµϺñȫ֤ǰȫЧģ
гؿɣʱƥ׺˵ҩｫΪǵĹ˾
Ϊ

Ϊһҩƥ׵ҵɹ˾̾ۼʡʱ
ǿдҩĻԻͣȻоǴĹʺˡá
Ρ ̨ʽֻǿһ㡱ƥ׽͵̴Ԥಡ
ֱƸಡ֢״ǰֱӾƸȾԼ
ĳҩ翹صȺǲͬƽߣ
ʮĩʮһ͵ĳҩִ ѪѹѪ֬
򲡼񼲲Ϊȫһҽҩгʮ;ʮ
̴ҩѪҩ򲡵ҩΪгƷ֣ʽ
ҩҩԼƲϰҩȵгݶҲг
Ҳӳҩ棬籾Ľߵĸҩ˾ҩ￪
ҾǸңŷƷϧӢ
һҲ̫ͨѧ˵ҶҩȤûһҩ
ȥͻ˵ӢˣЦҲôһ죿ʮ͵ĳҩ

References:

1.ҩＰ˾
ƥ(LipitorAtorvastatin (з)), ˾(Pfizer)
(Zocor, Simvastatin (ķ)), Ĭ˹˾(Merck)
(Mevacor/AltocorLovastatin (¦)), Ĭ˹˾(Merck)
˹(Lescol, Fluvastatin)ŵ˾(Novartis)
޷(Pravachol, Pravastatin)BMS˾(Bristol-Myers Squibb)
˹(Crestor, Rosuvastatin)˹-ղῨ˾ (AstraZeneca)
(Baycol, Cerivastatin)Ү˾(Bayer)
2.4Sо˹άķشо (Scandinavian Simvastatin 
Survival Study) 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase 
3-  -3-øAԭø
3.Simons, J. The $10 Billion PillLipitor Fortune, Monday, Jan. 6, 
2003 (´󲿷ݴӴժ¼ı)
4.Downton, C. Statinsthe heart of the matter Nature Reviews Drug 
Discovery, May, 2003, 343
5.Fogarty, M. Saving Statins The Scientist Vol. 17, 22, Nov.17, 
2003
6.Tremblay, J.-F. Lovastatin Chemical & Engineering News, June, 20, 
2005
7.www.yahoo.com 2004/07/26 Financial News: FDA Approves VYTORIN
ezetimibe/simvastatinthe First and Only Product to Deliver Powerful 
LDL Cholesterol Reduction through Dual Inhibition of the Two Sources 
of Cholesterol in One Tablet.
8.Quirk, J. et al Rosuvastatin calcium Nature Reviews Drug 
Discovery, 2, Oct. 2003
9.Link, M. Statin switch to OTC Nature Reviews Drug Discovery, 3, 
Aug. 2004
10.FDA rejects OTC statins Nature Reviews Drug Discovery, 4, Feb. 
2005

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Īáˮѧˮ

ߣ

йĻĸ鳤ɼܣ貿йĻί
ѧѧоչˮĻ֤ѵˣϸ߽İ䷢
֤飨£ա

˵1996꣬ϴѧϾУȿˡˮΣ
ϵ˳νڡĻܵѧĻӭйر
ϺǹݡڵغУˮѧоʿˮ
زĿơѡַⷿеһҪڣˡ
ձ顣

ѧΪĻ򣬿ѧоأоʲô˴ţˮѧΪ
ѡΣܵѧӭҲ޷ˡŷˮҲգǵɣ
عǡҪѡˮѧԻΪΪΪȶıҪ
ˡ

ˮǲǿѧ߼ʣ߼ǡרҹ۵㣬ˮѧ
ɷΪɣɺɡǰ߹עռ䣬ɽˮòط
һִѧȻһԡ˵Եķɫʡʲ
ô泡͸ϵһø˵Сȷװ޷
ʲô׵ȵȣһֲ۲۵ġαѧȻҲвٵĵ
ְҵˮʦڹŪ飬ѽһѧԵġˮѧݱΪ
Ϲƭ

⣬ʹˮѧЩ΢ɷִ֣СҪ
ΪִʹͳĲһռҲһŴĿռȣ
˵Ŀռ̫СѡĻ̫ˣԷˮԭԷá
սˮѧеࡰˡˡŲ˭ķӲ 
լ

£áˮʦ֤ͨΪʮУƺ
״СġͨΪáˮѧԻʻһ⽨
Ż̧ͷҲ˵ĵġŴΪѧ˶Ȼʶ
룬ණޡˮ⡪Ȼʹǧ
ǰҲŲ֡ҡ񡱡̫աʱ
ʲôһЩŨصķ⽨ɫʵĶٳΣ
᣿

ԡˮѧжߣԡˮйǧ۵Ļ
ΪɣҪ˵ǧĶǿѧġģô潼أǲ
ҲǡĻ

ӦǿѧԺ׵ߡάߣΪˮѧ
ԹĴСαѧ֮ӵĴ̵ƣǲӦõġ

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ˮ֤ѵŽʬ

: 

2005-09-07ձ   

ˮейУʷˣͶϲ±
ְҵûСˮʦλáˮʦܹ񺺵
ΪһֿԹ淶е𣿽գϾѧѧо׿
ˮĻ֤ѵרΪֳǶԴͳͻƣ£ա


ˮǿѧţǸʵǻ
ǴཫΪšǺԡˮȨ;ǡһšԼ
ɪڡйѧʷУҲȷѡˮαѧռһࡣ
ˣǵĹУˮѾΪšˣҪǡˮת
áˮ ʬ꣬ǿһ֡ͻơˣͻƵ
ġѧߣŵס˵ĿѧʶͽΪ
ŹƻһֱͱȽأ÷ˮ¿Ŀѧʶֽ
ʽ΢

ʶ֮ʿָ ˮѧһЩڿȷ֪ʶȻ
ЩȷĲȫǾģûγɿѧۡҽĳЩ
пѧĳɷ֣˵õʲôҩĶ֢Ƿдƹҽı
Ҫˮܽ٣

ѷˮѧơĸ߶ѵʵǣ

һһЩˮĻ֮Ƶ񺺡衱ȥ꣹·
ٰһˮ̳񺺲μˡмߺǽ˶Ի
ΪʱǻҺϵƬҪó𣿡ȻˣȻ϶Ҫ¡
ʽʱǻҺĶͷĶǽţѽײһ
⵽ǲţ

ᵼŻ̧ͷŴѧѧһ𡣶
ڶԣԳȻĶнֻͣڷˮЩ˱Ȼ
ŻƱ̧ͷνˮ̧ƺҲЩŻһ
ġ֧֡

ڴİʾȻѧԱѵ
ᳫˮˡݱΪռԽԽϡȱġˮء
ݷɽ͵ΪԼ׼Ĺػ㣬ԼԺİ
ҲȴеĺĹǼҫ飬ͬѧ
ʱȡİʾ»ǵ

ڴˣ߾ûǲҪڷˮϸʲôͷΪѧ֪ʶ
ĴѧãӦù֡šǡ׼šĶ

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ˮĻʦѧ

Ч
2005-9-7

Ͼĳѧѧоͽ貿йĻĵϾٰġ
ˮĻʦѵཫ101տ࣬ڹ״οչˮĻ
ʦ֤˺ϸ߿ɻý貿йĻİ䷢ġˮĻ
ִй٣ʦְҵʸ֤顣¡һӷˮΪŵĴͳ˼ά
ܵϾսŪҵͨһҲűˣ治֪
ѧΪĿա籨

йˮһֱΪΨ塢Ϊܵк
񶨡νġˮҲһֱܵѹȡޡֱ
ǰѧ߷£ԡˮȫλУʵ
ضѡ񶨾ӵĸԭγɾԺδũʱ
ҪһֳȻǿǶסĵصġǷ
ˮȻЩ꣬׾ѧо𣬡ˮѧˮĻֿʼ
УȻΪһǱĻΪһĻΪСΪڣ
ԶԶδܳΪĻһ飬ȫŷˮͷԷ
ˮߣԺΪڣˮѧƲǡȽĻ֪
ѧˮĻʦԹڵԶ׼

Ӧóϣ˶ѧˮ֪֮٣ҲϣѧΪһ
ϵѧʣΪлͳĻһ֣оļֵ
Ϊڶһѧʴ飬ǿѧţΨ廹Ψ
δ֮ܶǰȻԽѧۡ粵߼ǣ߼ʣ
о޳ɣȡҲ˶ѡԽѧо
ĽߣѧķΧһ˵Ŀѧ
ˮĻʦΪΣδʧ֮Ͻʧ֮ѧԣδЦ
󷽡

⣬УеĿĿѧ ˮѧѧ
ˮѧˮ뻷ˮѧִеӦá
ȣѵǼѧѧѧѧ֪ʶнˮ
ʵʿ졢ܵרҵ˲šߵĵĵǣűϿѧǩѧ
ʣ᲻ΪʿҡײƭĻΪĴˮŵ֤ͨ
Уƣ֤Υɷ桢ְҵ¹淶ɶӰ죬ȡ
ʸ񣬵µġˮŶܲס
һѧУ

ѰζǣˮĻʦ֤ѵֶռһר
ҵռѵʱΪ1ܣԷΪ5800Ԫ֤580Ԫʵеʦ
רҵѵʱ仹δȷøߴ19680ԪпԷ18800Ԫ֤
880Ԫһһ֣һɺϡһͷ

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ŮġƷ



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ǡиֵŲ̊ϵĳȻ2005ġй̨
һ˾޴ķ籩籩ȻԵڡڲ롱
עȴδԷγɵġ뷽ʽ

Ҷ򲻹עĩһڱͷȴͻȻһȺȺ
ˣԼǡסۡԡзTŸ
ʽӱԼֵ֧Ǻ·ˡ֧XXXͶXXX
һƱԲϤͶƱߣ䷳һ齲⡢ʾڵĲ
·˿ʼһͷˮĪ׾ȻȲġŮ
ġ˿ΪԼżƱʵһйⲻܲ˵
һ١죬һֱעйءƱϢɳϺɶ
ݡݡȫгжƱ

ԭӡŮѡʼָĺԮžԷԱԾ
Ըϲýַ֯ôԸֵЩ֯ԱȨ
ȷֹвͬĲ㼶쵼ԻЭˡټˡ糤ɳӱԮţ
ְȨΪһΪ᳤ͳ£ڶΪ߻
ͺĸšִ繤ߣʹʹزʶġ˿
ΪһͬĿߵһˡѡͨʹ˴˾
Ե֧չɫġƱһѡս
ԷγɵġƱ֯Ѹٺͳ죬ܲ
档ʵѾ߼ǿġ֯ѿʼ죬ǵĵ
һ

ͬοǣƱ̳飬ȴԣ޼ҵġ֫
ͻڡ˿ŮԵԭ򣬵ϾΪйġ
ѡĻһͷΪˣö֮пܳΪѡƱ
ϰߺʹͳ

ڴڿ񻶵ϷУȷܲشӰԶĹϰߺʹͳ
ǰۼҰͺսоŷ޵񻶽ڴͳָ񻶽
Щڶгɵʽݳʽǿǹٷǽ̻ᡢǹҵĿ
硢˵ĹϵĹ۵㣻ƺٷı˰˵ڶ
ڶ͵˶ڻСĳ̶ϲ룬һʱ
һ˫ϵоˡ
ĻӰ졣񻶻ͻȫԡԡ
ԺͶδΪ񻶻ԡųԣ񻶽ϴڵ
ڶгЦһ롰ٷ硱ͬġԼ硱
ʵϵ硱гЦԶԶġǸ硱
γա񻶻дԡԷԺƽԣʹ˵ıܵõй
ƽȲʵеĵȼɭϺ͸ɡ

񻶽ͨڹ㳡ϾУڰͺսġ񻶻Уڹ㳡
ԻռȻҪ塣Ϊ㳡ȫֻΪ
ӵУ޷¢ϡ˹̸Լġռۡܵͺս
۵ĳ

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ʦ 4750¶

ൺ籨2005.9.3

    ش³ϵƽʯǸƽС䣬
ȴһըţԭʵׯںͻȻˡʦ
һ50룬ʵθٽһϸ߳£Щ
䶯1ӣЩһشϱ³
ݵġߡľ𾪡˵صĴţҲ
ȫصļ߷׷ǰɷñ(92)ֳĿ
ݹ̣ȴ֡ߡʵ©ٳͬʱڼߵһٱ£
Բ˵

ˡ

ƽסַǼѵ飬
ߡİɣ⼸Ǽ߾岦һ
ĵĴ߸ߴ·߽˵ԭǴׯںԴȥ
ˡߡľҡһԶġ
ʦӣȥݵģŰʦѧյģɷõ˶콫ҵ
żˡ˵ţѾ߽ҵĳԺںﳤӢ
ɹ

Ǹׯں

ǼãԵúƽ߿ǰǸ͵
ׯںһ̴Ƥڣ˺ܾݡǴ21𣬲ſʼѧ
ߡġļ϶ȼһԾĺ̸˼ҳ
˵ʱǸ常ݵʦ常Ͻ书ڵغպ
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¶

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