                         ˿µϣ20060503գ

06.05.03, ԹߡϮҲٰɡСô
06.05.03, pathology2006ڶҽѧ˵ĿΪ
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ͼ1  Antimicrob. Agents. Chemother.ͼ2cFig 4c1186ҳ
A Novel Engineered Peptide, a Narrow-Spectrum Antibiotic,is 
Effective against Vancomycin-Resistant  Enterococcus faecalis 
Antimicrob. Agents. Chemother.2005;49(3):1184-1189

ͼ2 Nature Biotech еͼ4cFig 4c1483ҳ
An engineered mutidomain bactericidal peptide as a model for 
targeted antibiotics against specific bacteria
Nature Biotech. 2003;21(2):1480-1485

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ͼ3 Nature Biotech еͼ2fFig 2f1481ҳ
An engineered mutidomain bactericidal peptide as a model for 
targeted antibiotics against specific bacteria
Nature Biotech. 2003;21(2):1480-1485

ͼ4 Ĵѧѧҽѧ棩2003еͼ6Fig 6607ҳ
ҩɫ̶-һ˹Ŀʷӻ
Ĵѧѧҽѧ棩2003344605-609

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ͼ5 Nature Biotech еͼ1cFig 1c1481ҳ
An engineered mutidomain bactericidal peptide as a model for 
targeted antibiotics against specific bacteria
Nature Biotech. 2003;21(2):1480-1485

ͼ7 Journal of  Bacteriology.2004еͼ5Fig 58419ҳ
Effect of Mild Acid on Gene Expression in Staphylococcus aureus
Journal of  Bacteriology .2004186248407-8423

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Fig.3 Characterization of a Hemoglobin Protease Secreted by the 
Pathogenic Escherichia coli Strain EB1. J. Exp. Med.19981886
1091C1103

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pathology2006

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׼оʱס򡱡Ӻȱʧ
ֵڶҽѧεҽԺҽ£Ϊ

1.[1] SydneyD.Finkelstein[2] .ܰٴѧ
Ĺϵ.лѧ־,2001,30(3):183-187
2. ϳ .ڵܰͷ.лҽѧ
־,2001,81(5):271-273
3.[1] DemetrisAJ[2] FinkelsteinSD[2] ϳ[1].ϸ
ڵܰͲ.ڶҽѧѧ,2003,24(4):360-363
4.[1] SydneyD.Finkelstein[2] .΢иԸϸְ
Ӻȱʧо.,2003,23(1):19-21
5.,,־,ΰ,ϳ.ϸƻӺ
ȱʧ΢ǲȶо.лѧ־,2005,34(2):71-74

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1.2001лѧ־˵ܰٴѧ
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ߣ˫̱ɢֻԽͻҩĸã˵ֱ
á
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йʽıֽҲпԺϺҩоרҵɱ
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оر

̱200637 յ14桶й,Чҩ?
̱2006314 յ26桶 ˫̱ɢ---ڿһߵߡ
̱2006328 յ12桶 ߵġ
̱2006426  27桶Ȩרҽ⡷
ձ2005129ջšҽҩܿC

Ϻ̹ȼŹɢΥССӹиǵ˷ĳ
ĵز 20059Ժ̹ȼɢĺпԺϺҩоɱʽ
Ĺϣ

˫̱ɢȫ׸֥࿹ҩƷС
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ַ

200619յ13ϺʼҽԺȺҽﲿɢĺпԺ
ҩоɱʽ۵Ĺ£

ҽҩ޳浥λ޳ʱ䡢޳ַ
񽡿޳浥λ޳ʱ䡢޳ַ
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нκȫNMFig7ͼ

frankf

Ժʿ飬һҲô⣬ǰ˷ԣ
רҵģûӷԣNMFig7ͼ񣬷Ŵ˿
Լ10ͼģʽʶ𣬺ͳĹ飨ڵĹһ
缶Ĺ˾ЩӾֳ񣬿ͼ񣬵ͼӦʲô
зȨģ-----ͼɡ 

1±ԵͬһıCCDζ
ﲻġݸ˹ЧӦCCDĳ֮޷ֳ˷֮
ͼ񣬶Ҿ˺õķԡǡǡ÷ںڴԵǡǡ
Χ

2нѹĵ۸ƶϣܳͬ
ѹֻںڴΧġͬʱGIFͼôҲѹģ
ȽҲ͸˵ѹġ

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˵ĴŰ˵ŰĴǵĴѧǣ
ԼһûУ?޳ܲ޳ܣ

ǵصĿٵ治ˣļٲˡ κȫԲ
޷ڳΪԺʿɵľͿԳʵ ˵4ֻС
ԣ͸ߴʵǶ٣ܸòܣ˼˵ͼ
٣óͼЩǾ֮ͣҲӰǵܣ
ǹģ

ǲܳΪˣΪûʺƤҽ飬߷ɵ
·

1ΪߵԺΪΪ֮ƭᣬռ
Դթƭʮطɰǧƭйغ˵
ơթƭ

2߹ҽҩֺĿӣҶҽƲǲƵҽ
Ҳ˲ٽҽй٣û˵ߣ
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ʮ  ҽʦִҵУΥ涨Ϊ֮һģ
Ÿ辯ͣһִҵ
صģҽʦִҵ֤飻ɷģ׷Σ 

壩    䡢αҽѧ鼰йϵģ 
    ʹδ׼ʹõҩƷҩҽеģ 
ߣ    չ涨ʹҩƷҽöҩƷҩƷͷ
ҩƷģ 
ˣ    δ߻ͬ⣬Ի߽ʵٴҽƵģ 
ţ    й¶˽غģ 
ʮ    ְ֮㣬ȡǷܻ߲Ĳȡ
ģ 

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ʵо,ôΥ˵8, ڵʮͲ֪Ժʿͷڲ
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һκȫNature/Medicineͼ7aӡ



ڡκȫNature/Medicineͼ7·֡һ(XYS20060426)ж
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Ϊҵڳ룬λѶԷǳѧ̬ȣ
ҵؽһκȫNature/Medicineͼ7aӡ
ôҲӦˡ



(1)
(http://www.nature.com/nm/journal/v6/n10/full/nm1000_1160.html)κ
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Yush̽һ¡񻯡



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sharpeningԭͨأpixel֮ԱȣӾ
ͻĸоע⣺ֶԱȵӲܸıͼĲ֣ǷǺڼס
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ֱͼƬϸΧߵƵô׼д
ɨǣҪеĻYushݸƼһ¡

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أ ûɣ񵼵һֻҪĵطҪǺĳ
ĳ˵ɨκԺʿͬϸһӴձЮģǴձΪ˸л
йκΪ۹֢ķףרΪһ˿ģǾ˵ˡ

   ڡѹɵĴ׿򣬺ǺǣǸҲѽֻ˵ѹlosing
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¹ѹʲôformatͼƬϢֻٶӡҲֻнѹ
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YushκԺʿNMͼ7еġһֽ͡Ĵ

ߣѧҵ

YushѵĽǿסģ

1˵ǰǺúѧϰѧϰPhotoshop˵
ʹڰ׽ӵıԵԣܹʹ߽
߶ȵƽֱֱǾֱߣƽֱҪ
޷εƽֱŶphotoshopжԸͼмΡ
һ񻯡

2ĵڶվסŵģȡͼ7ɫϵߵ㼰
״ͼ΢ģ󡱲ΪƲ֤ݣͼȵ
ɨӡͼַ״ͼڵϺϳɣȽַ״ͼӡ
ӡͼһɨϳΪͬһͼġΪԺϳɵͼƬͬ
Ծڴɡߵ΢ģġ˵Ϊjpegѹ
ͬһͼϵİ׵׺ΧγԵİߵ㣬ҳѹȺܸߣ
۵ġܺ˺ڶjpegʽļͨ༭
γҿԳƽֱⷢһŹ
˱֤ܹͬͬʱַ֤װͼΧֻߵ΢ģ


ʵphotoshopȫκҪĽֻҪˮƽᡣн
photoshop֪ʶˣһ۾ͿԿͼǾϸĺڿ⴦˵ģ
޷֤䴦ǻʵƬǷʵƬ˵ˣóԭʼ
ƬgifͼƬ޷Ϊٵȷ֤ݣҲѹ޷Ϊûٵȷ
֤ݣǸйĴԺʿԭʼݶҹĸҹԭ
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ظѵ

н

ǺǣûдͿλѶ԰ļû취ֻٻ
һԽλѵˡ

Ȼشͷѵʡ1.˵ҪκṩĳֹС֤
ûаɡֻ˵һζҪƱǲԵġҲϣκʱίԱ
ǰṩӦĹС֤Գλ֮ʣֻ˵ǻϲǷƱ
ʽ2.ͷû֪ûشЩʲô3.Ϊʲô
κȵΪһѧɱʵ˵ط汨
Բ֪ΪģĿǰδִĿָκNMٵ֤
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пԺȻѧίйϽȨء˳شһ£˲ظʵ飬
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ȥԺκȥˡУݵʵҪ֤ݣΪһɣ
пм٣ŵĿǰҵĵģΪҵ֪ʶˮƽ
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ûôԡһƪͬôѧѧλ

homelyvoice

ԵѧλϢ

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ߡ ز 
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ʱ䡿 20030601 
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鱨ѧ20016

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ΪʲôСжǲͷ

Ϻ

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ֵһ־





лҽҩ־ҽҩѧ԰ػٹƽ̨ 
(XYS20060502)дҵΪйӰҪҽѧ
־֮һġлҽҩ־ҲԴشΨһĿҩˣ
Ϊ⡢ΪлĴ¡ʱٸн̹
ֻǱˮղò¸ݣ˵ϼڹѧڿĻ

˭֪йкܶһǱԺǰ׾Ʋһ
˶ʿעҩƷһзҩǿȵȣ
Ӧüڿһһʾҹ˴ޡų
ͳƣ20018889ڿǺǣ˭۵شﲩءлҽҩ־
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http://www.shouxi.net/journal/ϣΪǷ1ġ
ҽ־ԺȻĿлٴҽҩѧͷСǸʲ
ôɫhttp://www.cmmj.net/bottoms/intor-simple.aspϵĽܾ֪
ˡ

ڹڵҽÿ춼ῴšлй
оȴ־ĸԼҲͬ²֪飬Ȼеġӷ
һƪº󣬻ܻһֲ֪ˡ൥λѾף
Щǲõġлٴҽҩѧţ֪Ҫʱ
ǵĲԴ֪ʱܲҵĿԴ

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¿ܵ



,

йس¿ܵı, :

1. ӱٴҽԺվ, (http://www.bicr.bjmu.edu.cn/docdetail.asp?ID=1908)
һ, ѵַ֪ "2000񱱾ѧٴѧ 
Ժʿ2004UT MD. Anderson Cancer CenterزĲʿ2005
UT MD. Anderson Cancer CenterƲʿ" ĺ? 
ʿǿ˶ʿʿѧλõ? ʲôǲʿ?  ֮, ʿѧλ
ҲԻ, άٿƿĽ: "ʿѧһоְλָ
ѧȡòʿѧλ֮רŴо졣"ֻһְλ, 
Ա, ʦ, Ӧý"ĳĳλʿ", "ʿ". Ҿڲ
һЩ""ĺʿ, , ҪӸ"TENURE-TRACK"Ū. 
ʿͨнԪѾܺ, ͨʹ"NON TENURE-TRACK"
Ҫ. ο"TENURE-TRACK". ʿǲȶ, һҪʵϰ
Դ,һϰûǮ(ͨǸһ꿴һ), ǲʿְλû, Ҫı·. 
оǳ¿Ĳ֪ʿĺ, Ҳп.

2. ¿վû˵ıƽʷ, ѵ֪һᵽԼ 
ıƽ? ϲ鲻֪ıƱ, ""ı˿
ϲ. ûѾ, 鵽¿ܱҵ人ұƼѧҽѧԺ
(http://hdp.39.net/resourcecenter/DoctorDetail.aspx?ID=46321 ).  Ϊ֣ݴѧ人
ұƼѧҽѧԺΪ֪ͳ¿ܵĸУеź, ¿ܱ֪ҪЩ, 
2002վıѧУ.  ҽ¿ܰЩϢڱվӽȥ, 
"", ĸУҲһΪ㹦Ͷ. 

¿ܸ""ʿĽ, Ĳ, һڻǳ
, Ȳʿʿ, ""֮װ, ˵? Ҳʿֻͨʵ򽻵, 
Ҹ˵һûҽִո˿, ҲһûסԺҽʦ, ʱ
Ӧöѧоа, ٴûаֻ.

ϣĸλҪŹ"ë"صڵ""ȥŪ! Ѻ, ʵ
, һͬ, ûһ˸()Ǵʲôʲô"֮"ȥ. 

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ڡйƼ

huangzi

˹վ"йƼ"£˲ϵ
һȤ£

1йѧЭĹٷվġйƼ
http://www.cast.org.cn/n435777/n435796/n435877/n435880/appendix/fujian
1.docĵڶ涨"䲻40"Ӧȷʵŵġ

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ҵƵҳҲ˵"196411Ժл񹲺͹"

ԣǸý֯ߵĹΥˡйƼ
Ĺ涨ȻйƼʮһйƼ쵼ί
ԱȨ"䲻40"Ϊ2ǰ"䲻40
"Ҳ̫ˡ

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һָΪŪ

CHEST

51˿¡ҸѧСĵͨѶGeorge 
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صı༭ֻڶоĹסܹ֤
ʵݵ׼ȷԺͱʱŻΪһߡڹһЩ
ܹSCIѵƣڴ󲿷ֻ㵥λоԱȱѵ
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ְƵĿġ̳¶ݴѧźξһ
http://www7.tianya.cn/New/PublicForum/Content.asp?flag=1&idWriter=0&
Key=0&idArticle=644804&strItem=freeΪһָΪŪ
٣ݡͼƬϾҪգһҪԽֻҪһ
£ԴﵽͬĿģֻͶȡɣܻѧ硣

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ã

ÿϰĵһ¾Ǵ򿪵Կ˿һֱǱˮǰ
쿴йءѧԩǺУѧĿΪ
ѡ(XYS20060414)һģͬҵרҵϽӽҩҩģҶ
ר֪һԷһԼĿΪһЩҪ鷳Ŀǰ
ڹȥҵ䣬лл

ڡһֺά/άصÿҩרļ㿴



һ㣬ҩҩģר֪һҩ̫˽⣬
컹صũҵҩվϿһҩ̺Ҫ󣬾ͬ
ҩԶ

Ҿ߿ܶרҩ֮Ĳ̫˽⣬һҩＴʹר
ȨҩﻹĺԶҩרȨҪһҩ
ҪԭϵԴҪϣҶлܼĲͲƷĶ
øˣרȻֻҪнϺõЧɣĿڼ
ۡȻ¼רĻƭǮ
һҪ¶ġڹƭӺܶ࣬һʵֵķ
Ȩŷ֪ʶȨĻƭǮ紨ڡ

һڡ״氢άعұ׼ԭҩΥҷɡ


Ҹ˾òûдʵרҩϸ񣬷Ҫԭҩһ
кܸߵĴȣרܷΪһҩ¡

ڡñͪΪҩƼܼ桱

ʵǸ⣬רһҩ¡

ڡñͪҴܼȱʲƳΥ
ѧûʵԡ

ʵרЧԣһǹؼڣԼһרĹ
ԭģڹ֪ʶȨվϿȨԭģֻ֣Ҫһ
ҩ˶֪ǲʵֵģΥʵԡһģ
ʵ¬ΰҲǲʵֵģҹǳ
ļۣʵλӦðϧԼŶԡ

ҿһרԭҩЧʵͬۼƬûԵĲ
һʡ

λһ飬ԺʱñȽϴĿǲ
ЧһЩΪ׽һЩ

ָ֮

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ʸҽöǮ

DOREMIFA

˿, 05.12.22 ĴѧڶҽԺ żĵ"ҽ
ĵλ", ˵:ʡҽԺ,ʹķԼΪ2.4,ҽΪ1
𡣱ҽ, , Ҷʸҽ1˵ʮ
ֻ. ȻҲǸƵҽ, ֪, ھѪܴһҪ4-5
Сʱ, ҽҲԶò1. ֲ˵θС, ո, ʱ䳤2-4С
ʱ, ׶һҽ˵չ˾2ǧһ. Ҳǰǰõ. 
ƵʸһһСʱ, еĸҽ, þ
FELLOWSHIP(סԺҽѵ), շѸ1. ǰ, 
һԷ, Ԥз. ҽԺҽһ2ǧ, һ2
ǧ5,ȥǮ, ҼǲһǸߵ, . ҽǮ
вǰ,˳ʸ, . ҽԺסԺ, , B. Bķ
ҽ, ҽ, ҽǮ. ҽԺҽյõ, һ㶨
ۺͱչ˾ĸѲ. ؿЩ, һ. ڵҲǴ
Χ, úܸߵĵط, ҽշԸ߹õ͵ĵط. ҽͱ
չ˾̸շѱ׼. е˺ٵ, ҽּܿۻ. һ
ҽڶ, Աչ˾һշѱ׼, ܾܽͼ, 㲻ܾܽ
, ûּۻ۵Ŀ. ʹʡҽԺ,ҽǵɵ, ͬ, 㲻
, ʿٻбĸҽ. ҽӱչ˾õǮǵͳһ
, ҽ˶, ûûбҽת˵ҽ.  "ҽֻ
ܵõҽѵһ"ҲǲԵ. ˽ҽһԼ, סԺҽҽԺ
, òҽǲǮ. ǽѧҽԺûסԺҽסԺҽ, 
бĿҵҽ̨, շҪҽͺܶ. "ҽ
ҽƹûȹϵ,ҽƹ̫ҽܵн,
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Fighting against fabrications in China's academia

By Jia Hepng(China Daily)

China Daily 2006-04-29

Wei Yuquan, vice-president of Sichuan University and academician of 
the Chinese Academy of Sciences, has recently become famous but it's 
not because of a new academic achievement.

Instead, the lavished attention comes because Wei was accused of 
fabricating his papers.

Since late March, Si Lufang, a professor of immunology at Xi'an 
Jiaotong University, claims Wei fabricated two papers one of which was 
published in the world-renowned journal, Nature Medicine.

Wei's papers are about using pig tumour cells as therapeutic vaccines 
to repress the growth of tumours in mice.

Si told China Daily that the "very rough data" in Wei's papers 
suggested that "such an experiment might not have been done at all."

Si published his accusations on the website New Threads, which is 
known for its attack of academic misconduct.

Wei was unavailable for comment, but at a news conference held last 
week in Chengdu, Wei refuted Si's accusation, saying the claim was 
originated from personal enmity. He did not respond to Si's request to 
publish raw experiment data.

On April 15, Sichuan University announced that "in a proper time," it 
will invite scientists in the field and host a hearing where Si and 
Wei can counter each other.

Wei's accusation is not an isolated case. It is, however, one of the 
most high-profile incidents.

"Among many accusations we have made against paper fabrication, the 
involved person in this case has the highest academic position," said 
Fang Zhouzi, a US-trained biologist who operates New Threads. "We hope 
our efforts would result in an institutionalized system to curb 
academic misconducts in China."

More misconduct cases

Wei is not the first to be of the target of New Thread's academic 
misconduct outcry.

Last December, New Threads accused Qiu Xiaoqing, a professor of 
biomedicine at Sichuan University, of publishing fraudulent research 
in the November 2003 issue of Nature Biotechnology.

Chengdu-based company NTC Holding, which invested in the technology 
Qiu's paper described, claimed on New Threads website that the 
scientist's original results could not be repeated.

Sichuan University agreed to investigate the claims and declared on 
April 14 that Qiu's paper could be proved by repeated experiments. NTC 
Holding refused to accept the explanation, requiring the university to 
publicize the raw experiment data and appealing a third-party 
committee to redo the testing.

A month prior, Fang declared that Liu Dengyi, vice-president of 
Hefei-based Anhui Normal University, had falsely claimed co-authorship 
of his 2001 paper in the American Journal of Botany and of three 
papers in the journal Ecology in his online resume.

China Daily tried to call Liu's office, but the man answered the call 
refused to give a comment.

After the accusation, the papers in question disappeared from his 
online resume, and Anhui Normal University never conducted a formal 
investigation into the claim.

That same month, Fang claimed that professor Liu Hui of Beijing-based 
Tsinghua University had listed a paper by a US-based professor with a 
similar name on his resume that was listed on the university's website.

Liu said the mistake was not his own but a misprint by the Tsinghua 
Library, which compiled the list of papers. But after an investigation, 
Tsinghua confirmed Fang's accusation and Liu was fired.

Problem roots

Fang told China Daily that since 2000, New Threads has exposed 400 
cases of plagiarism, fabrication and other deceptions involving 
scientists faking their academic achievements.

Although most scientists Fang has accused claim their innocence, no 
one has yet accused Fang of libel.

In the majority of cases, few individuals have been seriously 
investigated or punished by the science authorities.

"The lack of severe punishment has led to the rampancy of plagiarism 
and fabrication," said Fang.

So far, Tsinghua's Liu is the only scientist who lost his job due to 
fabricating his resume. Previously, graduate students involved in 
paper plagiarism were dismissed in China.

In the West, a scientist who fabricated his or her papers would lose 
their fame for lifetime, but in China, according to Fang, wrongdoers 
are only investigated by their employers often universities and 
institutes which does not always mean their reputation is ruined.

He Shigang, a scientist at the Institute of Biophysics of CAS, said a 
supreme committee is needed to punish academic misconduct.

"So far, the Natural Science Foundation of China has made the most 
frequent punitive measures, but its power is no more than abolishing 
the wrongdoers' rights to apply for its grants," said He.

According to He, those brave enough to expose academic misconduct 
often face great pressure.

Si, now nearly 70 years old, said that in 2003, he had found Wei's 
paper in Nature Medicine was seriously flawed. He then wrote an 
article to point out the mistakes. But before he published this article, 
Si claims, Wei begged him not to print the piece.

At the news conference last week, Wei admitted he visited Si in Xi'an 
at that time, but it was because of etiquette.

Juan Carlos Lopez, editor-in-chief of Nature Medicine, confirmed on 
Monday that the journal was going to publish Si's correspondence 
challenging Wei's research and a rebuttal by Wei in 2003. Later Si 
requested to delay the publication time but the journal could not meet 
this demand and eventually gave up this article.

He Zuoxiu, a renowned physicist at CAS's Institute of Theoretical 
Physics, believes the rising commercialism in China has penetrated 
science, leading some researchers to falsify data or plagiarize 
others' work in order to gain fame or funding.

Zhu Xiaomin, a researcher at CAS's Institute of Science Policy and 
Management, said that the lack of supervision and transparency within 
the science community should be blamed for some scientists' misconducts.

"The public and media do not have the knowledge and capacity to judge 
what's right and what's plagiarism within the science society, and the 
self-disciplinary action of the scientists is the most important way 
of preventing academic conducts," Zhu said.

Actions to come

Starting early this year, after South Korean stem-cell scientist Hwang 
Woo-suk was found to have fabricated his published research, Chinese 
science authorities seemed to be enhancing efforts to fight academic 
misconduct, such as plagiarism and misuse of graduate students in 
advisor's research.

Lu Yongxiang, president of CAS, admitted at a recent session of China 
Science and Humanity Forum, that there were misuses of graduate 
students and other misconducts in CAS.

"If we found any case of this kind, we would decisively strike it 
without hesitation," Lu said.

In late March, Xu Guanhua, minister of Science and Technology, 
admitted publicly for the first time that unethical behaviour in the 
country's science community was a serious problem.

Speaking at a seminar last month, Xu said his ministry would reform 
the way it awards research funding in an attempt to tackle the problem.

On March 27, a spokesperson of the Ministry of Education told Beijing 
Morning Post that the ministry would set up an ethics committee to 
strengthen the fight against academic misconduct.

"Although Tsinghua's firing Liu Hui is still sporadic in the Chinese 
academia, this is a symbolic step, meaning the authorities eventually 
begin to face the problem," said He Shigang.

But Wu Weimin of Shanghai-based Tongji University, hopes that the 
strike against academic misconduct should be done by the official 
organs.

The unofficial disciplining actions of New Thread and media could 
cause misunderstanding and may be misleading.

"I hope the Chinese academic authorities will have the courage and 
capacity shown by the University of Seoul in the case of Hwang 
Woo-suk," said Fang.

(China Daily 04/29/2006 page11)

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