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            ٱš״ͬҽҩѧΪѧϵ

                            ӡ

    ڴţھٱձ200783տ
ġ״ͬҽҩѧΪѧϵһƭ˵ļš
FDAָļԭļ

http://www.fda.gov/cber/gdlns/altmed.pdf

    ļֻᵽҽǺӡȲҽһģ£

    ҽѧһʺҽʵƷƷ롮
桯򡮶ԿƷҽѧʵƷƷĲ졣ЩʽĲ
ҽѧҽӡȲҽѱʵ꣬ģƷ
ǸųֵġThe term "complementary and alternative 
medicine" (CAM) encompasses a wide array of health care practices, 
products, and therapies that are distinct from practices, products, 
and therapies used in "conventional" or "allopathic" medicine. Some 
forms of CAM, such as traditional Chinese medicine and Ayurvedic 
medicine, have been practiced for centuries, whereas others, such as 
electrotherapy, are more recent in origin.

    NCCAMҲҽѧģҽҩϵΪ漰Կ
Ʒ棩ҽѧػƽеݱۺʵϵЩ
ӳ˶صĻϵҽӡȲҽNCCAM describes whole 
medical systems as involving "complete systems of theory and practice 
that have evolved independently from or parallel to allopathic
(conventional) medicine."  These may reflect individual cultural 
systems, such as traditional Chinese medicine and Ayurvedic medicine.

    ⲻָ֪ʵҽӡȲҽƣ롰ҽѧ
ִҽѧ죬ʷһصĻϵ
ͬҽǸѧϵСѧһʣFDA
ҽҩƹܣѵйҽѧԺΪFDAйҩǿ
кͺŪȥģ

    FDAļصָΪļᵽĳƷʵƷ
ΪFDA֧any mention of a particular CAM therapy, practice, 
or product should not be construed as expressing FDA's support for or 
endorsement of that particular CAM therapy, practice,or product or, 
unless specified otherwise, as an agency determination that a particular 
product is safe and effective for its intended uses or is safe for use.
žϵ˿ܻƭҪļƭˡйҽѧԺ¿ɼԺʿ
ΪӢˮƽ̫ļҥƭˣǲٴ֤
ҽġʵλǿԴģ


״ͬҽҩѧΪѧϵ

http://www.sina.com.cn 2007080301:32 -ձ

82յ () ߽йҽѧԺϤʳ
ƷҩƷ(FDA)½һָļҽѧƷFDA
ָ()ҽҩڵĴͳҽѧӡҽѧ(CAM)з
״ͬҽҩѧҽѧһһۺʵ
ϵĶѧϵǶҽѧĲ䡣

йҽѧԺ¿ɼԺʿܣFDAһ2004귢ֲҩ
Ʒָϡ֮ļԻΪĵҽģʽ˳Ӧڲ
ҽѧٷչ״FDAҽҩƹܵĽ̶ܳ
ߣҩ˽ϻʵ̬ȡ

Ҳҽѧ(NCCAM)FDAΪͳҽѧϵǡ
ۺʵϵԿƷ(ҽѧͳƷ)ƽзչģ
ŶصĻбǾһЩͬԪأŻ
ƷҲж֮

(XYS20070803)

˿(www.xys.org)(xys.dxiong.com)(xys.freedns.us)(xys-reader.org)

ʱͬҽҩѧѧϵ

ߣ

Ͽһתձš״ͬҽҩѧΪ
ѧϵѾѸָһšﲹ伸䣺

1ⲻţһšձ200783յ11
šͬҽҩѧѧϵҪȽš
FDAָļͬҽҩѧǶѧϵһڡң
ڽ6£йҽҩͷΰ졢¿ɼĸϸ¡
FDA²ݰͬͳҽҩѧҽѧ¿ɼ˵ᵽFDA
200612¾ˡ

2ձ˵߽йҽѧԺϤʳƷҩƷ
(FDA)½һָļҽѧƷFDAָ
()ҽҩڵĴͳҽѧӡҽѧ(CAM)з
״ͬҽҩѧҽѧһһۺʵϵ
ѧϵǶҽѧĲ䡣λǴġ¿ɼ
˵һϸ

ȣòݰһشǶԲҽѧֳ
ҽѧǵݽ»֣ҽѧϵAlternative Medical 
SystemsCAMзȥΪҽѧϵWhole Medical 
SystemsͳҽҩTraditional Chinese MedicineTCM밢ӡ
ȲҩҽѧAyurvedic medicineһ롣ݰȷ˵ҽѧ
ϵCAMзȥΪҽѧϵԭҲҽѧ
ģNCCAMFDAΪҽѧϵӦʵCAMƷеࣨ
ѧƷ廥ҽѧðĦƷƷ
ͬ NCCAMĶ壬ҽѧϵǡۺʵϵԿ
ͳƷƽзչģŶصĻбǾ
һЩеԪأŻƿ漰Ӧ;
һЩȣ紫ͳҽҩӡȲҩҽѧӲݰݿԿFDAһ
̶ͬͳҽҩѧͳҽѧҽѧһһ
ۺʵϵĶĿѧϵǶҽѧҽѧһ
䣬 FDAʼҴͳҽѧҩľݣʾ
δҽҩƷгĸԺͿɲԡ

λȻҲǴġȣFDAĲݰûСҽѧϵ
Alternative Medical SystemsCAMзȥòݰԭ˵
CAMƷNCCAMе5࣬ҽѧϵΪ
ҽѧϵڳΪҽѧϵһķһ
[4ַಢе]࣬Ϊҽѧϵʹ4ַʵ
ʹCAMƷϵȻҲCAMһ֡ʵϣݲݰ
ʲôǲҽѧʱгABCDE55νġ
ҽѧϵwhole medicine systemwholeòҪɡ塱
Ϊνŷۡҽѧ㿴NCCAMվ
ڡʲôǲҽѧ˵
http://nccam.nih.gov/health/whatiscam/ͻᷢڡҪ͵Ĳ
ҽѧЩĿµһνġҽѧϵ

Σ¿ɼ˵ӲݰݿԿFDAһ̶ͬͳ
ҽҩѧͳҽѧҽѧһһۺʵϵ
ĶĿѧϵǹ󵼶ߡFDAûڲݰᵽҽҩѧ
ѧϵԭ˵ģNCCAM ҽѧϵΪ漰Կ
棩ҽѧƽݻʵϵǿܷӳ˶
ĻϵҽӡȲҩҽѧǡĻϵڳ¿ɼ
ıҡһͳˡѧϵ

Ȼ˭Ҳûзҽһϵһġϵ
δһѧϵһһõϵ

ЦǣĶ߻ܿǳ¿ɼԼĹ۵
ӲݰݿԿձͱˡʳƷҩ
Ʒ[]״ͬҽҩѧҽѧһһۺ
ʵϵĶѧϵ

Ż˵Ҳҽѧ(NCCAM)FDAΪͳҽѧ
ϵ[]ǾһЩͬԪأŻƷҲж
֮ȻݰԭĲûᵽʲô֮ԭֻ˵ҽѧ
ϵһЩԪذƵԼƿ漰ʹ
ǡ;ļɡֻһ֮Ա˰塣

3 FDAݰر˵ˣڸļСᵽκضCAMƷʵ
ƷܽΪFDAضCAMƷʵƷֻ֧Ͽɡ

4Ҳ֪ߺͳ¿ɼǷ񿴶˸òݰ¿ɼ˵
ǿӢģΪ˺ƣFDAʼҴͳ
ҽѧҩľݣʾδҽҩƷгĸԺͿ
ԡôأټд֮ǰӦöһԭģӦֱ
¿ɼ˷һŸɣ

(XYS20070803)

˿(www.xys.org)(xys.dxiong.com)(xys.freedns.us)(xys-reader.org)

޳ܵĻ
״ͬҽҽһΪѧϵ 

ߣ

ڸվת˿ڡձ11棬ɸñ
дΪ״ͬҽҽһΪѧϵı(
http://world.people.com.cn/GB/1029/42355/6064834.html»
http://news.xinhuanet.com/tech/2007-08/03/content_6467689.htm)
˵ ʳƷҩƷ֣ƣģ½һָļ
ҽѧƷƣģָϣ壩ҽҩڵĴͳҽѧӡ
ҽѧãͣз״ͬҽҩѧҽѧһ
һۺʵϵĶѧϵǶҽѧ
䡣 

FDAָϳѹҳϣ¸ʱ200732ա
ַhttp://www.fda.gov/cber/gdlns/altmed.htmҲʽıɹ
http://www.fda.gov/cber/gdlns/altmed.pdf߸ȤԼȫ
ֶԭĵ˵ʲô 

һ۸壬ļǷ棬ֻһΪʳ
ױƷʳƷʳƷӼҽеҩƷҵȷƷǷӦӡ
ԼӦFDAʲôṩ˵ 

ȣձıԸıķͲȷԭı
(Guidance for Industry  on Complementary and Alternative Medicine 
Products and their Regulation by the Food and Drug Administration)
ӦӦΪҵָϣҽѧƷƣģ桷漰
ָǡʳƷҩƷͻױƷ(the Federal Food, Drug, and 
Cosmetic Act) Լ񷨡(Public Health Service Act). 

áָϡĵһҳһξȷָҽѧ(е
ҽѧ)ҽֱ˵ذҽҽѧ
CAM(ҽѧ) ԭǡSome forms of CAM, such as traditional 
Chinese medicine and Ayurvedic medicine, have been practiced for 
centuries(ĳЩҽѧҽӡȲҽѾչ
͡)  

ָϡȻˡҽѧƷ ࡣһƷ
(Biologically-based practices) (ڴ) ֲƷȡƷ
άƷ֬ȵȡָָЩƷ;ͬп
ʳƷҩƷױƷ߼ʳӶӦءʳƷҩƷͻ
ױƷ  (Energy therapies) (
ųͳ) Լδ֤ʵⳡ(νﳡ) ơָ
ָƵепܱΪҽеӶӦءʳƷҩ
ƷͻױƷ ںͻƷ(Manipulative and 
body-based methods) Ħá׵ָѹƷָָ
ƷʹκеҩܡʳƷҩƷͻױƷ 
ߡ񷨡 Ĺ淶ʹ˰Ħ֮࣬п
ط档 ģ(Mind-body medicine) Ʒ
졢̫ȭƵȡָָFDAһ㲻淶ƣ
ʹеƷпFDA档 

ĸඨ֮󣬸ָ˵NCCAM(Ҳҽѧ
) е࣬Сҽѧϵͳ(ҲΪҽѧϵͳ) 
ڽ俴ΪһĿĿٺĸಢУΪҽ
ѧϵͳ ʹĸзָ˲NCCAMķ෨ 
Ȼ󣬸ָϵڶΣҲһᵽ˴ͳҽ˵NCCAMҽ
ѧϵͳΪڳҽѧƽзչģۺƷ 
Щҽѧ˶صĻϵͳҽӡȲҽҽѧϵͳһ
Щͬ(ע⣬˵ҽͳҽѧйͬ)
ƻĳЩʹǡķ  

⣬ȫᵽҽпؿ 

һָϡȷҽӡȲҽڡҽѧϵȷָ
ϵʹCAM(ҽѧ) ĸз仰˵
áָϡΪҽCAMΪҽʹCAMֶεĴӻ⡣ 

ָϡҽ ѧϵ Ϊҽѧ
һ෴νӡȲҽУָǵĹ֮ͬһ
β 

ձıνFDAҽҩڵĴͳҽѧӡ
ҽѧãͣз״ͬҽҩѧҽѧһ
һۺʵϵĶѧϵǶҽѧĲ
䡱 ȫ졢˵Ļԡ 

(XYS20070803)

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Ӽšͬҽҩѧѧϵýʧ

ߣgopher

ͬҽҩѧѧϵý屨Ǽţʵʳ
ƷҩƷָûͬνҽҩѧġѧϵȻ
Ϊһ֡ҽѧ

γģϸһ飬ԴͷԼǰйҽҩϳ¿
һƪҽеܲ⣬󱻼߱Դˣһе
ΪʵվΪá

׷⡢̽ѯ౾ýְҵʹǼӦְҵ̬ȣ
õݡʵӦ֮رԴ
һͲڵʵеġѧϵֱ
վʵʵԶﴫ೴򲻽ý
Ĺý塰ԼΪ桱Ķ

ʵ鵽FDAڲҽѧĲݰҳԺʵѣȴ
ûһýʵ˶ԣûýϢԴ
ʵ塣˲ɻ󣺱ӦʵΪýΪ
סʵ

ʧʵʵʲýҵߵˮƽ⣬̬⡣ӡȫϢ
ѧ߱ϣŵϿѧٵͬ
ҽҩѧѧϵͬ汾֮ƵƵ֣Խ
Դгס˲ý弰ҵԱ۾ǳ
ƫ׷αѧý侺һյĽ죬һЩý彫
Ϊг档ýġ߱λ޿ɺǣʵԡ
һע׽Ӱȡ裬Ū٣˷档

ͬҽҩѧѧϵţǲǡΨָ
ý ȵ㡱ĵͰҽϰϢϢأ֮Ŀǰ
ҽҩչά裬ҽϴ֮ȷǶ߹עȵ㡣ýûк
ʵʵýץˡҲǡСƲ
ˣͬҽҩѧѧϵҥųΪű


ý縺ۼලЭеΣý岻
ʱǡΪڸ˻ռ޵£ͨý
ʶʵġΪԴʹߣýϢǿӰ
ӦܵԺ͹ԵԼеΡýʧʵȻ¹
ڶʵĴжϣγɴۣ۴ﵽһ̶ʱӰ
Ťľߡ磬ϵ͡ѧϵĲ𣬾Ӱ쵽
ǶҽЧԵжϡǣ΢һ£ڶ۵
⡣

ŷý岻ʵŽбҪٴ조άʵԡ
ľӣ

лĵĴ󲿷Դġҥȡҽýʧ桷
http: //news.people.com.cn/GB/37454/37459/4994390.html߽
ģʾлرĴβģΪ˴
ӦЧ

(XYS20070803)

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ɾйҽѧԺձ

 lyoung

ΪӡFDAһֱҽ,ҩǲҩ,ν
ҩֻڳеһֱƷ,Կ""ܾ.æȥFDAĹ
վwww.fda.govһ,7µ8ƺûпκκCAMHerb
.Ȼgoogleһ "FDA CAM"ؼ,ȴôһ:

5/9/2007 - The Council for Responsible Nutrition (CRN) has 
reported that the US Food & Drug Administration's CAM guidance fosters 
misinformation that certain Complementary and Alternative Medicine 
products should be regulated as drugs.

,ԭmisinformation.Ǻ,һ󴫵"",
59ѾFDA,ΪҽоԺ,ù<ձ>ȴȻ8
2Żܼ? һʱĺ.....

(XYS20070803)

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ҽ۵սƪ

ߣ7·ȥ԰

ļٲˣٵ治ˡ

ҽĲУôôڻ塢ҡͳ֮Ĵñ
ҲûãݹŴҽĴͳۣǵ˻ؽʯ
ɵ鵤ҩţŮΪ˾ТҪԼ˳ţЩ
ͳôû˼ţ

𰸺ܼ򵥣ΪǴģȻͲäĿļְ˶ǶԵĺ
ģǻִʲôţ

ڵй˶ɵš

˾ǴˣԾǲԣԵľǶԵģЧ˭Ҳ񶨲ˡ

ҽҽѧȻҽѧҪҽƵĽ˵⿿˵棬
к壿

ǽкʲô桢֮ģı֡
ҽЧôԼͻȺھͻҪ

ǣΪʲôڵҽԺԽԽࡢſڵĲųӣҽԺ
ȴԽԽҲٵĶࣿ⻹ڹҴ֧ҽ£
Ҳ֧ţһҽѧҪͳĻһұŹӣⲻ
ҽѵӦúúҷ˼һ

ҪǳĴ죬б¾ͳβִܰҽѧβ˵Ĳ
ˣܹ´ﵽҽˮƽĻҽȻ
棬Ҫκİ

ʲôĻѧ֮ģȥȥҪҽĺȣ
Ҳ뽭ƭӳҪҽȥƭϰա

ҽͺúܽβݣһЩʵʼֵġ
Ķ֮Ķǿ̸

ǶйˣûҪǸԼĶȥ˵Ƕġ
һЩţҽǲǸúúõҷ˼һɵųţ

úÿǿǣΪʲôҲ˵ȡҽƫ˵ȡҽţ

ҽ˵Ի֡˫۹ȥˣ⿿˵ֻƬ
ţôҪԣԼͰԼˡ

(XYS20070803)

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ҽҩǲǿǿȡޣк裬֥

jhuang

ִһҪǲʲô͸ʲô
ڸΪֱӷˣɶ˵˺(
ĸŮϿߵ)ִƲûߵ
ɣҽҩҲһк裬˫˥ߣ۵Ĳҽ
ͽҲѣͳϡֲƻ̬ƽ⣬ǣ
˾͸ˡˣӦǿƴʩԸһвר
׼ҩҽͽҪάԼġȨϽУԸ̹ѹ
ǹ򣬲Ʒ

(XYS20070803)

˿(www.xys.org)(xys.dxiong.com)(xys.freedns.us)(xys-reader.org)

ҽ֮ĸ

ߣfrank1952

ڶСҽ۵¿˺ܶ࣬ҵĸζȫ

ҸеǾϲҷ˿˵ҵһ
ʶӡŹҫͨڡҽ۲ſʼġ˿
֪ԭһഺ磬԰УȻ
ȥбС˾µα漰Ȼѧ֪ʶҾ
ô󲿷ֶܾʡЩƼ٣¶ҩٱƷıƺ˵£
ϰ˵˻ԭѧʶԨһˡҸоǶ
Ŀѧ̬桢Ͻһֹ۵Ĳоݣʹ˲ò
塣йӡˮƽӦڡֻ
Ǹվ˻ޡйܶһЩˣγйǿ
γйٱƲ

ҲҹƼȻ潲
жŮĻҺ޲˫굽طȥҼֱţ21
ͣÿƼ﷢13˵йĿе
Ƽ

ҵҲܳأǹҵϰױơϣϰ
վǵĿѧ̫ˣˮƽҲߣ
λ˵öʵˣֱ׳ظһ飬شԺ
ʿ⡣˵˼ٻϰյǸⲻС¡

ϣӡӡŹҫܶ෢£ǵǻۺӰ
Ĺˡй˵ļй˵ϣǣй
ˮŲ̫롣

(XYS20070803)

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ԭʿŽֹǿԺʿBMCLŪһ¼ŽĻظĳЩǳ

ߣcometit

˿Ͽѧͽڽ¶ԭʿŽ͵ʦСԱ
ֹǿBMCLŪһµżԼŽĻظ˶ԴҲ
ͦȤоһ󣬱ĳЩǳҲ̸̸

żᵽŽBMCLеĹҵǰˣ
£žͲ֮ٸͷ棬ԼֹǿͨѶ
߷ʹ±ŽĺBMCL£µ
ʵʣ

1ŽǸѧעо

ȤԵŽĵϢ˶ʿ
ϢжȷдŽΪѧҵĲʿʦ͡
 BMCLĲʿĻ乤Ӧڸѧ
֣ݴѧлѧϴҶϵġʹͶôã
Ʒô㶼ܷ񶨸ѧƪеȨ

Ϊĳҳ

http://so.huntmine.com/view_article_7471_0.html 

Studies on Synthesis & Biological Activities of Natural and Synthetic Piperidine Derivatives
 Ž;
ʦ ;
ѧλ赥λ ѧ ;
ѧרҵơ ҩﻯѧ
ѧλȡ 2005
ļ ʿ
Ͷˡ ѧ
Ͷʱ䡿 2005-09-19
ؼʡ  ; -3- ; 1-л ;  ; GABAת˵; GAT-1; ; Wittig Ӧ; Գƴ߻⻯Ӧ ;
ӢĹؼʡ piperidine; nipecotic acid; 1-benzylidene-1,2,3,4- tetrahydroisoquinoline;alkaloids; GAT-1; anti-epileptics; Wittig reaction; asymmetric hydrogenation;

ȻĻǷȻɱֳ翹ס
ǡȶֶԡڲ鶯ڵһɷ, 
нǿϵͳ, -3-ʾ˽Ϻõ GABAת˵
ƻԡ GABAת˵Ƽ(GAT-1) ĿǰѳΪɸѡҩ
Ҫбꡣ

2ŽBMCLݶĲʿġ

ɴ˶ʿݿпɲ鵽ŽȫԼڷ
BMCL ¶Աȿ֪ȤĿȥرȽϱȽϡ۾Ǻܺã
еôСͷˣĳվһļ
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ʿб ( ) ҩѧѧб( )  BMCL Ͷб                                                                                                                 ( )

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*25b (240.0)                  5b (240)                                                5b (240)

*25c (4800)                   5c (4800)                                             5c (4800)

*25d (2130)                   5d (2130)                                             5d (2130)

*26a (0.920)                  6a (0.92)                                              6a (0.92)

*26b (1.180)                  6b (1.18)                                              6b (1.18)

*26c (589.0)                  6c (589)                                                6c (589)

*26d (105.0)                  6d (105)                                                6d (105)

*30a (16.90)                  δд£                                5'a (11.60)

*30b (15.80)                  δд£                                5'b (15.80)

*30c ()                        δд£                                5'c (120)

*30d (17.80)                  δд£                                5'd (16.90)

control tiagabine (0.081) (R)-tiagabine(0.08)                         3 (0.08)

Control (456)        (R)-nipecotic acid(456)                          1 (456)


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Synthesis and biological evaluation of (R)-N- 
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hydrochlorides as novel GABA uptake inhibitors. Bioorganic & Medicinal 
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