                           ˿µϣ20100301գ

10.02.28ûи
10.03.01, ˿־Ը߾ٱФĹ
10.03.01, Ԥ˭ҥߣ
10.03.01, ɽҥиС
10.03.01, ꡶֡תСĻ
10.03.01, Latino2Ůʿתˮ˵
10.03.01, ظҲʿµĨתˮǧŻųꣿ
10.03.01, ƽ֧תǶ䣿δء
10.03.01, HenryҲ˵ƽ
10.03.01, ԡʦѧԺصȺԴѧ
10.03.01, ˮɵȫ磬ҲҪֺα
10.03.01, ˡһֲ
10.03.01, zeroyearڡšеĴ
10.03.01, зЧ Ȩתñָ
10.03.01, An Open Letter of Complaint against the Xiao Procedure

˿(www.xys.org)(xys4.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)

˿־Ը߾ٱФĹ

һȺ־ԸߣĿǰйءФϢͿɵ
Σ𾪡ФйФʵ
ѻ˵µԴ԰ףйҽ
ٴ顣

˿վwww.xys.orgڴйѧܡԺ
١ͨ˿ФѧΪĽ¶ǲŻ֪˸
꣬һֱиٵйص¼ԸЧͷ
ԽԽеǡҲйýĹע䷢ĵ鱨
ʾ൱𾪡

ڴ˹Уǽйظʵܽ£ٴ
ԺNIHҽԺίԱᣨIRBԼ
μӻпܲμĻߵĹע

1. йĹʦǾδҵ֤һФɹ
෴Ƿ˴غ֢ĲʦѼ200692007
 3֣ԴҽԺ110λ绰74
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2. λ״ԴҽԺ໼Ҳߡָع㷺
Ф85%ɹʡǡǰãФָʾФ
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3. ФĲѱƭ֡СФԴҽ
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Ϊȫɹ˳ɰǧĻȻԱ
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С

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5. йٷФļ߹λרҼԱָ
ڼϲǩ֣ݵĽṩǵѡĲ
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ա

6. ФĻԭԱɡרǶФȱѧ֤Լ
δгʵٴͲµʵʩ˹עλרҲ
Феѧͼ֣Щʵǿѹǰױ
񾭹ܲδָרǻĳЩ
йܵĸƣͬʱĳ˨ϵɽѡ
ж͵̼ЧФЧ磬ФSIU 
2009󡰰׹5ȫָܹǹ˵Ů̺֯
ǳأɽӦ֢ҵǣФδФ
飬ФȴйصҽԺչӪÿλ
ȡԼԪ

7. Фһֱ鹹ĳɹ磬ѳƻˡ
ѧɾͽ磬ФԳƹĹźܸߵۣʵ
ФļٱͬáЩʵ˿عФ
Ϊ˿˷ӽ10Ρ⣬Фĸ˼¼۵㡣磬
乤оֹӶ˷ˣ߷Ժ
˹˾һ¹˾Фǳ˾Ҳ
ˡ

8. ĿǰٴڿݡݵһЩؼݣ
Фڡŷ򡷷һƪõһݻ鱨档Ȼ
ƪؼĻ鱨ȴиҲˣФƪ
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9. й֮ٴĽBeaumontҽԺƵ˹
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˵ɵеȫSCIʧܣӦԭ
Фʧܣ俼ǵФɹͶʵй
SCIġNIH飬Ϊ񾭴Ƽѵİȫ͹Ч
ἹˣⱾ˵⡣ФSCIʧܹڡ
ѡ󡱺͡ǰٲֱBeaumontҽԺSB
ɹڡ㷺ǰBeaumontҽԺһ걨棩
ͬSBɹִ

10. BeaumontҽԺ˴йФ鹹񻰡ڻشѯʱ
BeaumontҽԺṩϢФйġ 
йҽԺÿ춼ʵǣФδΪйĳ
ֻѹرյԴҽԺֻФ
⣬BeaumontҽԺ鲡ȥй
ڽ飬ҡ̫족BeaumontҽԺʽܲȥйܿ
ѾغФġٴ־վѾ90
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Ԫ

ʵشԺίԱᡢҽԺԼ
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1. ǺNIHIRB˹Фٴľȫ
Ф˵Ĳ20032005꡶־15 SCI20
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SIU 20092006ԴҽԺ1406ͬʱФƵ90
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ṩϸԭʼϡ

2. ǺйҽԺֹͣٴ飬ȴˡǽЩҽԺ
ԼФѾĲǵйϸĻǸ
ս BeaumontҽԺNIHվĿܣر𶽴BeaumontҽԺ
Ф90

3. NIHҽԺڽеٴѾФй
ΪNIH׼ٴӦóɹ12̨ȫɹ˹
ҽѧ硱⽫󵼸໼ߡ

4. Ҹ滼ǣھμٴйǰҪؿ
ǡǹĻΪԼ˵ҸվԼΡͬ
ʱǽýҪȡ˵ʲôȡФǼҽԺ¡

˿־Ը

20100225

ԣ

ǽͨԺίԱϼල
ͬʱǽõʼ͸йصоԱҽй
ý塣ǻӭر󵼻Ϣֵĳ
ϣԱⲡϣѰʱƭ

ǽԼݣԱԼФĶⱨФ
廪ѧĽϣĿǡ¡׬Ǯ𡱡ǰ
ȷвеһЩˣԡԷӣҲ᲻ϧ
ķʽ𡱡

ΪṩϢźӢýı嵥԰
˿ͷӵ¼ǻйʦýФı
Ӣķ롣

ż
http://xysblogs.org/wp-content/blogs/107/uploads/xpletter.html
ںýɷѯʼxysergroup @ gmail.com
ڲԣhttp://xysblogs.org/xysergroup/

Ӣİ 
http://xysblogs.org/wp-content/blogs/107/uploads/xpletter.html

Eddieʸݡ˿־Ը߲μ˹Ÿķ
УԣblobfishEddie fuzzifygadflyjames_hussein_bond
lightmanPoohHunny2èwhoamiʸڶѶԹź͸
дͽ顣

(XYS20100301)

˿(www.xys.org)(xys4.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)

Ԥ˭ҥߣ

ߣ
ѧ20103

22021賿һ򡰵ҥԡɽС̫ԭ
ΡȪȵزȺڳҹð߳Ŷܵ𡣼󹫰
5ҥ˲֮̾С

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ѧҡԤýһЩվĿǰ޷׼
ȷԤ˲ܹ֣ĴʡȴһĪظһ
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ҥԡƣ̶ںߡԽܵǣĴʡ
ֶԤݼԼ󱨵ԭûи
һ˵

󱨣˵Ǻġǰ˵ģȫ
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Ҳǿסģһ棬ȴܳһ㣬ΪҪְԤ
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ͨѡٷ롰ʶԵڵԤ
ϣйٷĵѧĹ۵Ǳ۵ġ
һЩԤԱʹõȫѧķͬһЩѧ
ҡʹõķ廨ţһЩαѧ㲻ϣ
죻緶ΧڣйӵһӴĹٷԤ
ĹҾ޽С

˵ĵǡ¡ʷԭ
һѡѧҡ͡ԤߡڲñֻԭȵĴ
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תйص𡢵ѧĻоԼԤ⣻߿ʼơ
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ȡҲʡǮЧĹǶԹڽȷĿգ
ǵеԾ֪ʶǣǰ׼ȷĶԤ
٣ڶһ㣬ҲͲٱЩҥߡơ
Ƕ˵ָһ֡ԤĴʵҲһ
ƭһҥһСˡҥ֮Եóѵǰᡣ

(XYS20100301)

˿(www.xys.org)(xys4.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)

ɽҥи

ߣ
(http://blog.sina.com.cn/s/blog_487ab9d50100hbog.html)

220ҹ䵽21賿ɽҥ¼Ѿȥһܶˣ
˵ˣΪ̫ԭˣԻ̲ס˵䡣

һĵӡһΡһ19891019賿
1ʱĴͬ-6.1̫ԭиУұѺ󣬷ִһ
ڶ90С𼶺ͷʱʱ鲻
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ˡǵϴѧ20014207ʱ3.6
ںΪ뱱ܽоԡ봨Ϊ
ʱڻϣȫûио

СʱҲһεҥԵĴ19912µĴڼ䣬Ϊ
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˵̫ԭܿ컹ᷢĵҼǵĸ׼ҵһҼң
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ѡȥԶ㿪һռ泰ЦǵųΪĸ
˲ٽڲͳԱǱʱˮ
ȻֻŹȥ֮Щֶĸóˡ

ڣ19ȥˣ벻̫ԭһΣһ䱾
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1991ĵֻкδȺ¼ⲻҰ̾
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ʵ֢ͳڵԤϡ۵ΪԤ
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ǰѾù˿AmselԤй
αѧ֮һνġѧʼ1966ӱ̨ܶ
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֣ôܸĿ˵Ԥأ

ԣҪõԤαѧ˳ҿϵͳֻֿܣ
һ֣йɲԱ;ʧĴ𣬴ӶʹԤ
Ŀгʧȥһִֵ֣Խݣһ
ѧרҵʿŵԤһֵĿԿ²󣬵
ҲʮԺˡһ̾

ǼȻָֻǿԼˡϣÿһ
ƪĵѶסĵ㣺

1. ڿԤƵĽܾȷԤǹ۵㣻

2. һƿԾȷԤ۶ǻԣһд¾ȷԤ
˶ƭӣ

3. Ը˵ЧԤʧİ취ֻסܸߵķ
ѧһЩԾȼ˵֪ʶ

4. ־㲻ԤҲдĹҪڴ
Ѹȷ𼶡ΪԮṩҪοԡרҲ󡡱
֮Ļ֪ԡ

㲻ͬĵ㣬Ҳ㲻Ҫƪĺ淢ˡҲ
ۣΪѾԵרҵĻ˵̫ˣʵǷˡ
ҷģǽһΡ

2010.02.28-03.01 

(XYS20100301)

˿(www.xys.org)(xys4.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)

֡תСĻ

ߣ

ũҵͳƣ2009꣬ת󶹣׺޻ֲ
ռȫ91%85%88%תֲΪ10.26Ķ
൱ȫй57%ֲת

ǣûת---Сҵֲ

ԭڣ

1ѡʳУСŴתΪѵת
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ѧҲųɹõһתС󡣶ҳȱҪӦüֵĿƷ
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ļֵԲСֲӲΣԲСҪ׻
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ҵ˾ƿӲƷʸתС

3߽ܶȵ͡ŷޣձͺڶתСĵִ
ֱӵ2004ɽ˾ݼתСƹ㣨Roundup 
ReadyƿũС󣩡

й෴һֱڻƺƹת
---Сֱ2004ܴ졣

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˰ȫ֤飬йתˮ䷢֤8ꡣ

ң2004׼׼ת---СӲʺɫС
ҵֲɽ˾롣гӦѣɽ˾Ͷ
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ɽ˾2004511շתСģƹƻԭ
ɽִиܲÿ-˵ɽתСƻҵ
ȷôһƻתСĿ
we recognise the business opportunities with Roundup Ready spring 
wheat are less attractive relative to Monsanto's other commercial 
priorities.'This decision allows us to defer commercial development of 
Roundup Ready wheat, in order to align with the potential 
commercialisation of other biotechnology traits in wheat.'

ߵϰ߶Ըı䣬ʹС߶Դ˾Բ
ԡ

ʱŷˣձСҪڹʾתС
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һЩҶתʳƷϸʩʹСֲҵߵսľҲƸ
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ԷǺתСз䵽С˫족
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Եġ

ڣ1š͡BT63Ÿոõȫ֤飬ֻ൱
2001תСܲߵ2004һĿǰȫȷ

ĿǰȫûҪĶϲֻǡת򡱴ףû
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ΪתƷֽͨƷ󶨣֤
ӾӪ֤󣬷ɽҵҲ˵ԼҪ4-5ʱ
䣬ܽҵ

ңĿǰ׼ǡ1š͡Bt63ںʡӦ
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תˮҲпͨƷ󶨶زۣҲпΪũ״
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ԭһûкõתСƷ֣ũתת
󶹣ףʹСֲ½2008ʳΣʹø
߼һЩ֯תʳƷĿı䡣5ת
ķչʵߵ̬ɶܽתʳƷߵӡ

ȻȻڡɽ˾תСƻ֮
Լ300С֯ɽ飬ɽһУǾͽǮ
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δũҵ޵У10תֲÿ԰ٷ֮10
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(XYS20100301)

˿(www.xys.org)(xys4.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)

Ůʿתˮ˵

ߣLatino2

Ůʿдйձᵽתˮĺ
ѡȨ

ΪһϵеȨУ׵ǵѡȨǻû
תˮͨתʳƷȨûȨҪ
ũҵǶԷתʳƷƫã

ⱾûߵȨġⲢΪũҵ
׼תˮɡ

ΪԸתʳƷҲѡȨ ͬʣǻû
תʳƷȨ Ϊʲô׼תˮҵʹã

ŮʿʣѵԸתʳƷ Ϊ
˲(籾)ң ſѧ֪ʶռ ˻ԽԽࡣ

ϷĳĶǸԵӡʹת򿹳漼
ͲСҩҩɸũҩˡ ϣת򿹳
Ӹϱ֤߲ũҩĶ

ָεĶǸйСģɢũƷģ
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ŮʿʵתʳƷгϵıʶ⣬
׼תʳƷе⡣

ߵѡȨⷽԲFDA 1) תʳƷҪ
ʾ 2) תתʳƷԸʶ (˵ԼתƷ) 1)2)
FDAṩϸݡ

ϲתĿԵ Whole Food Store ȥԩͷ 
ɡ 㲻ܼܰתʳƷɡ

Plus, ũҲѡȨԼũҩãũҩˣ Σ
ΪʲôũѡȨ

תˮĺʲôѡȨ

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ΪתˮĹؼⲻǷȫǵȨܷ
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׼ֲתˮʵԵģҲѾ飺йǷӦ
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֣ĴתˮǴ𷴶߶＼"֪"ת
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۾ԶûᡣҪģϰյȨ
õء

һϵеȨУ׵ǵѡȨǻûвת
ˮͨתʳƷȨûȨҪũҵ
ǶԷתʳƷƫã

ҿԽתˮǰȫ˵Ҳϲһû
׼ʱ˰ǿӸҡ˭ҲӦѡԼϲʳȨ
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Ĳûɡǰת޻ǲ֪У
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"תѾйؿ

ллأת޲ʳǽľǽڵת
ףǼǵʳгȻЩתʳƷ
ֱѶͨӹ뷨Լ

ˣתɷֵʳȻǲԸǿӸ
ǵġũҵʵ϶ȨûиһεĽ͡
ڣ־ҵֲתˮˣһΣЩƫͳˮˣ
ٷѡȨˡȨܾתˮǿӵǵĲϣ
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仰˵ҵֲתˮľɸģҲ
ȡЧĴʩֲ֤Խ׼ı߽磬ҲԷתˮ
ȾκΥ涨ΪȷĴ

漰һȨǵ֪ȨǲӦ֪л
ϵʳƷǷתɷ֡ǻӦ֪⡣

磬ǱȨ֪תˮǽ21ʳΨһ
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The earth's nearby moon is about 2.17 times as effective as the 
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ҩжҽԺҩǲʵ

(XYS20100301)

˿(www.xys.org)(xys4.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)

An Open Letter of Complaint against the Xiao Procedure

February 25, 2010

We are a group of volunteers who are alarmed by the ongoing public misrepresentation and misinformation on an experimental surgical procedure invented by Xiao Chuanguo, M.D., from China. The procedure, sometimes referred to as Xiao Procedure, is designed to treat neurogenic bladder due to spina bifida or spinal cord injury and has been undergoing clinical trials in China, United States, and a few other countries.

We initially learned about this procedure when Dr. Xiao was exposed for committing several academic misconducts on the New Threads (www.xys.org), a website that is committed to fighting against Chinas academic corruption, plagiarism, and fraud. In the last five years, we have been closely following the case and have become seriously concerned about the effectiveness of the Xiao procedure and the risks associated with it. Indeed, the problems of the procedure have recently drawn the attention of Chinese media, and extremely shocking findings have been published after investigations.

In this Letter, we summarize a few facts about the procedure below. We hope to bring them to the attention of the National Institutes of Health (NIH) who funds the trials, and the institutional review boards (IRBs) of the hospitals where the trials are currently undergoing, and any current or potential patients of the trials.

1. In China, an independent investigation by pro-bono lawyers has so far not been able to identify or confirm a single successful case of the Xiao Procedure. Instead, the investigation has discovered numerous cases of severe side effects. The lawyers collected a list of 110 patients who had undergone the procedure at Shenyuan Hospital in Zhengzhou, China, between September, 2006, and March, 2007, and interviewed 74 of them by telephone. They found that 73% of the patients reported that the procedure had produced no effect and 39% of the patients experienced various degrees of complications after surgery, including weakness, atrophy, deformity and lameness in lower limbs. Before the investigation, some of the patients who received the treatment together had already gotten in touch among themselves, and realized that there was no successful case among them.

2. Two victims of the Xiao Procedure have recently filed lawsuits against Shenyuan Hospital. We expect that more patients will follow. The patients claimed that they were misled by the widely advertised 85% success rate of the procedure. Shortly before the litigation started, Shenyuan Hospital, a local, private and for-profit entity, of which Dr. Xiao owns 30% of the shares himself, was dissolved under Dr. Xiaos order.

3. Dr. Xiaos most famous case has since turned out to be all a hype. A boy by the nickname Little Shanshan was the very first patient treated by Dr. Xiao at Shenyuan Hospital. His cure was widely hailed in Chinese media and frequently cited by Shenyuan Hospital and Dr. Xiao himself as the proof of the success, inspiring hundreds of patients for the procedure. When investigators finally reached Little Shanshan, they found that he had never gained the ability of voluntary voiding but developed a limping gait. His mother revealed that Shenyuan doctors used to have him drink a lot of water and apply electric stimulus to help him urinate during demonstrations.

4. An official document testifying the 85% success rate was discovered to be a fraud. On February 28, 2007, Shenyuan Hospital issued a certificate of cure rate when Dr. Xiao Chuanguo was applying to become a member of the prestigious Chinese Academy of Sciences (CAS). It claimed that the hospital had applied the procedure to 117 patients since January 2006, sixty cases were followed up for more than 8 months, 85% of the patients have recovered normal bladder and bowel functions. However, the hospital itself did not come into existence until August 2006 and only conducted its first operation on Little Shanshan on August 13 of that year. There was simply not enough time for it to have conducted a more than 8 month follow-up study.

5. The official appraisal of the Xiao Procedure in China was just a formality. A few members of an expert panel that evaluated the Xiao Procedure have since spoken out that they practically rubber-stamped their appraisal based on partial information selectively presented to them including the name-recognition of Dr. Xiaos advisor, Dr. Xiaos self-claimed fame abroad, and Dr. Xiaos self-claimed success rate. The panel determined the procedure to be world advanced, which was frequently advertised by Shenyuan Hospital. On the other hand, another critical opinion from the panel has never been disclosed to the public: (the procedure) carries very high risks.

6. The fundamentals of the Xiao Procedure is still in doubt. Top experts in China have expressed their concerns over the lack of scientific basis of the procedure and the unethical practices without adequate and proper clinical trials. One of the experts examined the urodynamic diagrams presented in Dr. Xiaos publications and found that the urination of some patients was actually due to the benefits from the intra-abdominal pressure instead of the detrusor pressure, suggesting the failure of recovery of neurological function of the bladder after surgery. The experts also suspect that the improvement of voiding functions in some patients might be the effects of conventional surgeries conducted simultaneously or subsequently, such as detethering, selective sacral rhizotomy, or electric stimulus, rather than that of the Xiao Procedure itself. For example, the girl who was reported by Dr. Xiao at SIU 2009 gained complete bladder control in 5 months after surgery, reportedly had very severe scar tissue in her gunshot wound, which is exactly the indication of detethering. Unfortunately, there is so far no controlled study, either by Dr. Xiao or a third-party, after the procedure has long been implemented by Dr. Xiao in his associated hospitals, for a fee of 30,000 RMB (4,400 USD) per patient.

7. Dr. Xiao has long been untruthful about or exaggerating his works. In one instance, he lied about winning the America Urological Association (AUA) Achievement Award in his resume. He also claimed his work was well recognized internationally, despite the fact that his publications were seldomly cited by his peers. After such facts had been exposed on the New Threads, he filed about 10 lawsuits for libel against Dr. Fang Zhouzi, the owner of the website. Dr. Xiao also has a spotty personal record. For example, his employment at a research institute was once terminated prematurely, leading to a legal dispute in a U. S. Court of Appeals, which he lost. Another case in a civil court that involved a warden suggested that Dr. Xiao was once put in jail. He lost that case as well.

8. The current clinical trials in the United States are based on dubious data. The key data that these trials are based appears to be from a conference report by Dr. Xiao, which was cited by a review article by Dr. Xiao published in European Urology. However, this important conference report is in fact non-existent in the literature. Nevertheless, the review article became the major reference of the U.S. trials. Comparing to the information from other sources, the success rate and the number of patients cited in Dr. Xiaos article are very suspicious. Moreover, in a press release, William Beaumont Hospitals, who started the clinical trial in the U.S. in December, 2006 (Identifier: NCT00378664) and obtained a grant from the NIH in December 2009 (Project Number: 1R01DK084034-01), reiterated Dr. Xiaos claim of almost 90-percent success rate, indicating that the trial at Beaumont was solely based on Dr. Xiaos own assertion without any qualification. Furthermore, doctors at the All Childrens Hospital (ACH) mislabeled its trial as double-blind, indicating that either they lacked the understanding of the basic principle of clinical trials, or they (or Dr. Xiao himself) had no knowledge about the indications of the Xiao Procedure and the special pre-, intra- and postoperative care of the patients who receive the procedure, at least until the trial began in March 2009.

9. The outcomes of clinical trials outside China were not promising as claimed by Beaumont Hospitals. Firstly, the NIH sponsored multi-million-dollar trial (Grant Number: 5R01DK053063) on spinal cord injury (SCI) conducted by New York University (NYU) from 1999 to 2006 has so far produced no official result, except for a conference abstract that reported two cases with results that are much worse than Dr. Xiaos (mean PVR=200 cc in NYUs report vs. 31 cc in Dr. Xiaos first 15 SCI patients, for example). Secondly, the information presented in Beaumonts one-year report on spina bifida (SB) cases were selective and rather vague. There was no mention of the SCI cases, although the purpose of the trial was initially for both SCI and SB (see ClinicalTrials.gov registry), and its first procedure was for SCI, which garnered national attention and appeared in more than 160 news outlets (see Beaumonts website). There was no pre- and post-operative comparison, which should be essential for a clinical report. The mean and standard deviation of postoperative urodynamic data were much worse than what Dr. Xiao had reported (mean PVR=119 cc in Beaumonts report vs. 23.67 cc in Dr. Xiaos first 20 SB patients, for example), which should invalidate his claims to some extent. The side effects were also understated. Thirdly, according to Dr. Xiaos presentation at SIU 2009, all of the 6 SCI cases in Germany had failed (only 2 showed some improvement). Meanwhile, according to the media, all 3 patients with SCI at Beaumont were also not helped by the procedure. Statistically, the failure of all third-party SCI cases may proclaim the failure of the principle of the Xiao Procedure, especially considering that the success of Dr. Xiaos very first human trials and animal studies were all of SCI. The recent NIH-funded trial was entitled Safety and Efficacy of Nerve Rerouting for Treating Neurogenic Bladder in Spina Bifida without mentioning SCI, which may speak for itself. Finally, Dr. Xiao blamed the failure of SCI cases to incorrect patient selection and inappropriate postoperative care. The former indicates, at least in part, the success of Beaumonts SB patients was due to extensive preoperative evaluation (see Beaumonts one year report); the latter contradicts the success of Beaumonts SB patients who should have received the same postoperative care.

10. Beaumont Hospitals propagated the myth of the Xiao Procedure to patients. In response to patients inquiries, Beaumont repeatedly provided false information that the procedure is now standard of care in China and is done everyday in hospitals in China. The fact is that the procedure has never become standard of care in China. In the more recent years, the now-closed Shenyuan Hospital was the only institute that performed this surgery. Dr. Xiaos team is so far the only one that performs it. Furthermore, Beaumont suggested patients going to China for the surgery, in spite of that the surgery is still under trial in the U.S. and the results are too immature. Beaumonts indiscreet reference might have resulted in serious consequences: more than 90 U.S. patients had been successfully treated by the procedure, as announced by the website of Dr. Xiaos Chinese Journal of Clinical Urology; and each foreign patient was charged about 20,000 USD, as disclosed online by a patient.

Based on the above facts, we wish to provide our following suggestions to the NIH, the IRBs of the related hospitals, as well as to patients and the media.

1. We appeal to the NIH and the IRBs to review their decision on clinical trials of the Xiao Procedure by independently and comprehensively re-investigating the 15 SCI and 20 SB cases published in the Journal of Urology 2003 and 2005, the unpublished 92 SCI and 110 SB cases cited in European Urology 2006, and the 1406 cases since 2006 at Shenyuan Hospital presented at SIU 2009, all by Dr. Xiao, along with the more than 90 U.S. cases treated by Dr. Xiao, the 2 cases at NYU, the 6 cases in Germany, as well as the 12 cases at Beaumont and the 8 cases at ACH. Dr. Xiao should have the obligation to present detailed original clinical data of his cases.

2. We appeal the related hospitals to suspend the trials immediately, pending the review. We suggest that the hospitals thoroughly examine the cases already conducted by themselves and Dr. Xiao. Considering that in China rigorous follow up is challenging (see Beaumonts project description at the NIH website), we particularly urge Beaumont Hospitals to help Dr. Xiao conduct follow-ups of his 90 U.S. patients.

3. We caution the NIH and the related hospitals that the ongoing clinical trials in the United States have been distorted by Dr. Xiao in China as the success of the NIH approved clinical implementation, and all surgeries completely succeeded, astonishing the international medical communities, which may mislead more patients.

4. We advise patients to think twice when considering to participate in the clinical trials or to go for the treatment in China. We encourage patients who already received the procedure to come forward and report their status for the well-being of themselves and of others. Meanwhile, we suggest that the media should listen to patients as well, instead of relying solely on the stories put forward by Dr. Xiao and a few hospitals.

New Threads Volunteers

P.S.

We send this letter to the NIH and the IRBs or the overseeing authorities through postal mail by our representative. Meanwhile, we send the letter through email to the researchers and doctors that are involved or concerned, as well as the media who have reported related issues. We welcome for the letter to be posted on the internet, especially where the misleading or false information appears, so as to prevent patients from being misled or cheated when they eagerly search the web for a cure.

We do not disclose our identities to the public, in order to protect ourselves from retaliation from Dr. Xiao, who declared that his life goals are welldoing, money and revenge in his recent talk in Tsinghua University. Dr. Xiao has explicitly threatened some of us in various occasions before, and recently asserted in one of his internet posts that I would not hesitate to avenge Fan Zhouzi in the most treacherous way.

To provide background information, we enclose a list of reports from prestigious English media, for a better understanding of the activities of the New Threads and Dr. Fang Zhouzi. We also enclose the English translation of reports regarding the Xiao Procedure from Chinese media and lawyers.

This letter and the enclosed documents are publicly available at:
http://xysblogs.org/wp-content/blogs/107/uploads/xpletter.html
For public and media inquiries, please send your emails to:
xysergroup @ gmail.com
or leave your comments on our blog at:
http://xysblogs.org/xysergroup/

The Chinese translation of this letter and the original Chinese reports can be found at:
http://xysblogs.org/wp-content/blogs/107/uploads/xpletterc.html

This letter was drafted by Eddie and Yush. The following New Threads volunteers participated in the translation and proofreading of the enclosed documents: blobfish, Eddie, fuzzify, gadfly, james_hussein_bond, lightman, PoohHunny2, Sanjiaomao, whoami and Yush. Numerous volunteers provided their comments and suggestions on the writing or the translation.

(XYS20100301)

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