                           ˿µϣ2015328գ

15.03.20-267ûи
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15.03.28, غϼ292015.03.16-20

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Ƶ˽۽33ڣѷΪ顱

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Ԫù硰սʤѧ

ߣԶ

ԪȥѧԺѧ¬ڵɣ
𱬡Ƶ֮һЩ顣󣬸ѧԺ˽һ
ƪΪŽѧѶǵˡָŽӦпѧ
ѧҲӦýӦúӡý塣

Ӧ˵Ƶѧʦ룬Ƕýӡ
ԿѧʵȷЩⲻǶýĵӣǶ󵼵ķŭ
ʵϣ¬ڱý󵼵ļ֮С۵ʱ
Ԫʻƽ׵ת˼ʱ¬ԵЩȣԥ֮ش
Ȼ󣬴޴˵߸ǺϰӡУһ
С޻ģ˵שʹ˲ʵרҵʿ
ڵĻشʵȴ޵Ĵ𰸸רҵ˻֪һϸʣ
һֱۼɡ

ԣԿѧĻӦÿѧý鼼֮
ջ𣬲ܰѶԴý崫ı뷴УΪȺ֮ĶȻ
ںϡƫܡ

źǣڵʱõҪôʶ˱ۼɵҵˮ
ƽ⣬ҪôǶԿѧĺӡźǣֶԿѧ
ӣǵֳ֮һҪ⣬ǡ෴ý
ŵרҵϡ

ʲôʲô⣬ϣһšʵԴѡ⡣
ûѧţʱһ򵥵֪ʶҲףݣһԴ
ȨܲţԴרҡѧߣԴͨ
ˡʵʹרҵӳʶҲȻȻ򡣡񷶥
֮¡Σ񷶥֮¡ԴȨġɿ
Աѧҡ

źǣתİȫѧϣһδŹߵ
ѡԴȴһĿĿѧңȴ⵽˳Ц
ýϱΪŹѡԴרҵǶȣԪ
ѡд衢ת֯ΪԴѧҡFDAũҵ
ڱһġⲻûпѧû

ԪӦȥѧԺʲôأļ¼ƬרҵǶȣ
ļ¼Ƭ磬Ź߸ԣΪʲôԴѡ
ûиزѧعŵĹ۵㣬ѡһЩ
ĿѧңɷõרҷֵĲԭ嵽ʲôΪʲôܹŵ
ĳɹڸ֮ڣˣĳǷ߼ìܣ

Ȼһǲרҵ壬ǣԼãЩ⣬Щɣ
Ҫѧ߳ⱾŹóĵطҪ֪ʹ
רҵڿ͹ۻϵ߼ȴǷ굶ý屾
ΡȥһС

ʵϣʵҲˡЩ⣬ϡ΢϶㷺ҵ
ۣʶý˵У۶ת̬ΣԴԪļ¼Ƭ
רҵжҲһߵġԣЩ⣬ڵûбἰ
ûбۣûбɣ治֪һԪȥһרҵѧԺ嵽
Ϊѧ׷𣿿׷TFBOYS׷Ԫõö࣬룬
TFBOYSķ˿δӰй˵ǸȺ塣

ĳ̶ֳϣƵʧ֮ڣڳδŹֳ߳
жڴԪñۣ̬ȶԴԿѧ빵ͨ
ʱΪΪýˣӮǵԣ
©ٳļ¼Ƭڵû⵽ɣĳϣġר
ҵԵĳš

ʵϣԴ֮⣬ΧתĺۣܶҲý
ѧ⣬⡣

ѧоʵϴ󣬿ѧоڴ˵
ǿѧҵ飬˵ý顣ڽͿѧо
ѧҿѡɣһֱеΡôνǶȣ
ͿѧýΡʵϣŹߵĿѧ
Ϊ˸õڽͿѧҵĹ

͹ǿ͹۴ڣ˻ǵ·Ӱˮѧ
뼼һֱĴɣУŹ߸ǣ͹
ԵذȨݸڡ򵥵˵Ӧýѧҵ
ǳд

ͬʱŹ߲ǡվڹڵѧҷʡ
վڹڵѧҹ磬Դѡȼ󵼴ڡϾ
ЩΪѾԶý塰ѡɡѾͻýĵˡźǣ
ŽѧѶǵˡһƬǿýʵȨ
ýȷؽͿѧΡ

ʵϣȨε򣬲ǽڵ֪ȨʵҸȨ
ûʵ֮бȦӵġСýѧҵĻȨ
УȻ¹ʧ

ʵУ֪ȨϵڱʵʵĳɱҪǣ
֪ȨǿƱʾȻһǣʾתĲȫԣ
Ҫ֪ȨǷΥֲȻǺģǣκһ͹۵
ýˣӦΪȫ⣬Դڵ밵
ʾǣЩý˲ǿһ㣬ȴ֪֮ȨΥ
ֲȥʾ󵼰ȫ⡣¬ڸһ㡣

ѷ֣ʵ漰ѧǡ෴漰ý
רҵ⡣̵ǣϣһЩý˷Ĵ
ġѧǶתʶ㡱һޣ֪Ȩġ
ءʶ㣬ΪֻҪվڡ֪ȨϣͿԲɴ
иӰ죬ͿԡԶ³ԣԳ衱

ԣڼ¼ƬлԣǲɷõʱŹҪ
ȨԴǶԿѧչۼɣҽʱѡ
רһѡ⣻Ҫ֪Ȩذʾȫ
⣬ǰѿյжѧ磬Լһɵɣ
Ƕ֪ȨӰʶ㣬ǽ֪ȨҸȨⶼý
Ŀѧ⣬ý˵רҵ⡣ʵϣƫܰýרҵ
͵ýĿѧѧý⣬Ҳר
ҵ⡣

ӹԣйŹԺܶԼ裬Ѻѡ
֮УἤȺͬǣΣڿ͹
ϵĲţ໥ԣŹͬڡ

רҵӦһýȥʵķۡ۴ˣ
ѷַϵ⣬ˣҲ⡣ԣר
ҵԣöѧѧҲ̫Զ

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Ԫţ

ߣϽ

˴Ԫڸѧ͸ѧԺ¬ڱתƵ

Ԫ¬ڻƽת˶ٸ¬˵2ԪԴ
ȷ˵ƽת7򣬲ݴѧĽڲ֪ת˶
ûʸ˵ȫԵ⡣ƽ״ûת7򣬵һ
3ڶ¬˵2(LCYBǱ룩һ
׵PSY򣨰ⷬѺغϳøһϸCRTI򣨺ܲȥ
øԪһ֪ʶʾһý˵֪
Դ

û˽еĿѧ֪ʶԾĳ֪ʶ˽Ⲣɳܡʹ
ѧĽڲ˽ƽת˶ٻҲûʲôΪѧйص
֪ʶöʤ٣κνڶȫաؼǣӦϢԴ
жϵתǷȫһѧ⣬Ӧ
ȨжϣĻߴԪжϡתʲô
򣬻ιǷкܻͨش⣬Ҳһѧ
ܻش⡣

Ԫ¬ûѧûʸۣת򣩣
ʦ̳ѧ֣Ž繲ͬΪת򲻿
Կѧͬ˵Ӯ߼Զֳ֪
Ц͸ԪĻ¬ڵġԪƾֻ۵ǵ
ƤӼɣùһЦΪĬˮƽ

ֳı۲Ҫ֪ʶĻۣҪ߼ͼɣӭԪȥ
ѧһʦܿѧҲܼɺ߼

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йѧԺֲиڿ˷

ߣ

ֲ󡰿иڿ˷˿ֲ
иڿ˷

ȻǶԿиڿˣΪʲôֻԸкУоԱпˣ
ǿЧֵûɡ

ʹͬǸСУҲֲͬȼֻ3-5к͸
пˣԱ쵼ڼԱпˣ˵Լˣֻ
ǰ쵼ڼԱпˣȷʵе˼ԳɹͳеĿ
ﵽһ׼ĿԱЩԱΪģȻģ
ڱ̭ĿܣΪʲôҪЩԱɱеƼԹ
ȻѸΪʲôҪл󣿿Ա˽̴ṩ
еĸСвμӿˣȷʵеѧʡ

ֲ쵼߿ʵӦԱرڶ
ֲֻҪһеЧع
бҪ7쵼⼸꣬쵼Ϊ˽Լ˵ľҵ⣬ŵ
ԱӲ١Աһ룬ЧʻߡֲŨĹٱλ
Լֲչĸԭ

ֲ׼࿪ֿԱΥ¹涨ֲĿԱ
ԼֲûԱĹʱϣƾʲôҪͣԱĸ
λͼЧֲ˽蹫֮ɡ

ֲȱ˲šѣȱǹƽ塣ֳ
Ⱥ壬۸ȨߣǱֲʲôĻͿ֪

(XYS20150328)

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ũҵѧʤһֲճ

ʦ

    ãũҵѧʤĳϮintroductionһֲĵĳ
ϮϺͨѧġĽھȻΪ࣬껹ҿƼ

Role of nsdA in negative regulation of antibiotic production and 
morphological differentiation in Streptomyces bingchengensis.
J Antibiot (Tokyo).  2009; 62(6):309-13 (ISSN: 0021-8820)
Wang XJ; Guo SL; Guo WQ; Xi D; Xiang WS
School of Life Science, Northeast Agricultural University, Harbin, 
China.

Pathway-specific regulatory genes, such as actII-orf4, redD, cdaR and 
mmyR, are at the bottom of the regulatory network, each controlling 
one antibiotic biosynthetic pathway.3 Global regulators, such as 
bldA,4 bldB,5 bldD6 and bldG,7 perform the highest level regulation 
and affect both morphological and physiological differentiation.8, 9 
At intermediate levels in the regulatory cascades, many regulatory 
genes, such as afsB,10 abaA,11 absB,12 afsK-afsR13, 14 and tcrA,15 and 
two-component systems, such as afsQ1-afsQ2,16 absA1-absA2,17, 18 
cutS-cutR19 and phoR-phoP,20 have been identified, which regulate the 
synthesis of two or more antibiotics. absA1-absA2, cutS-cutR, phoR-phoP, 
tcrA and some pathway-specific repressors regulate antibiotic 
production in a negative manner, as mutations in these genes resulted 
in the overproduction of the corresponding antibiotic(s). Global 
regulators may also play a negative role, as in the case of the 
A-factor receptor protein, ArpA, in Streptomyces griseus. When 
A-factor is absent, ArpA binds to the adpA promoter and represses the 
expression of AdpA, which is an activator of a regulon that consists 
of operons involved in mycelial differentiation and antibiotic 
production. The arpA-null mutants produced more streptomycin and 
formed aerial hyphae earlier than the wild-type strain did.21, 22, 23 
Recent microarray data have indicated a cross-regulation among 
disparate antibiotic biosynthetic pathways and even some 
backregulation from cluster-situated regulators to a higher level 
pleiotropic regulatory gene.24 
The identification of new genes that regulate antibiotic biosynthesis 
and mycelial differentiation is important for understanding the 
factors affecting antibiotic yield. In this study, we report the 
identification of a new gene, nsdA, negatively affecting both processes. 


Identification of a Gene Negatively Affecting Antibiotic Production 
and Morphological Differentiation in Streptomyces coelicolor A3(2)?
Wencheng Li,1 Xin Ying,1 Yuzheng Guo,1 Zhen Yu,1 Xiufen Zhou,1,2 Zixin 
Deng,1,2 Helen Kieser,3 Keith F. Chater,3 andMeifeng Tao1,*
J Bacteriol. 2006 Dec; 188(24): 8368C8375.
Published online 2006 Oct 13. doi:  10.1128/JB.00933-06
PMCID: PMC1698255

Pathway-specific regulatory genes, such as actII-orf4, redD, cdaR, and 
mmyR, are at the bottom of the regulatory network, each controlling 
one antibiotic biosynthetic pathway (4). Global regulators, such as 
bldA (16), bldB (14), bldD (15), and bldG (5), perform the 
highest-level regulation and affect both morphological and 
physiological differentiation (9, 10). At intermediate levels in the 
regulatory cascades, many regulatory genes, such as afsB (22), abaA 
(17), absB (7), afsK-afsR (21, 36), and tcrA (33), and two-component 
systems, such as afsQ1-afsQ2 (26), absA1-absA2 (1, 42), cutS-cutR (8), 
and phoR-phoP (44), have been identified that regulate the synthesis 
of two or more antibiotics. absA1-absA2, cutS-cutR, phoR-phoP, and 
tcrA and some pathway-specific repressors regulate antibiotic 
production in a negative way, since null mutations in these genes 
resulted in the overproduction of the corresponding antibiotic(s). 
Global regulators may also play a negative role, as in the case of the 
A-factor receptor protein ArpA in Streptomyces griseus. When A-factor 
is absent, ArpA binds to the adpA promoter and represses the 
expression of AdpA, which is an activator of a regulon that consists 
of operons involved in mycelial differentiation and antibiotic 
production. arpA-null mutants produced more streptomycin and formed 
aerial hyphae earlier than did the wild-type strain (39). Recent 
microarray data have indicated a cross-regulation among disparate 
antibiotic biosynthetic pathways and even some back regulation from 
cluster-situated regulators to a higher level pleiotropic 
regulatory gene (23).
The identification of new genes that regulate antibiotic biosynthesis 
and mycelial differentiation is important for understanding the 
factors affecting antibiotic yield. In this study, we report the 
identification of a new gene negatively affecting both processes.

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ΪαջɽѧԺѧӪ

ߣRex Evolution

ɽѧԺίÿһȵġѧӪֿĻˡû
ѧյĿվȴΪʵαջ

Ķһ֧вҩСֶӡ

߽У԰̯λ㿴ϰŸвҩ̯λ˻
·ƷϵĸֲҩĽ˵ƣȫôͳҽԣСζ
龭ĿûдЧɷ֡

Щжõġȫҩ˵ȴûж䶾Ӧе
˵ɵٷʴήԣ˵ȴû
гκζá

ҽһĻǿѧſյţﴫͳҽۣǲ
۵αաԶò˵ǶԱաߵĽ
Ϊ

ѧӪȥѧѹزϵ¿ճ
ɸء

ͼƬҵĿռ
http://user.qzone.qq.com/3063991417/photo/V12qGEMk2QWZDZ/batchid/1426916766417000

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췽ҹ̷instructorɽʦţɲ

ߣASH

Instructorɡ󡱻϶ʿڹĹʣ
ӢĻ롰senior postdoctitleڣҲǸ
ܺõķ롣

InstructorǼ򵥵ɣ˴·׾г⣬


1תΪinstructorƺźĳƺ
ǡresearch associateתΪinstructorҪвڼΪǰᣬ
õϰƾٺѧУ׼

2InstructorнѧΪоΪࡣѧΪĹֻҪпοϣ
бϵģ˵ֻʱоΪinstructor벩ʿ
ȣ乤ȶҲǸһĲԼ뵽
fundingûоԵ룬assistant professoròtenureҲˡ
Tenured professoròû㹻Ľѧ񣬶Ҳǻᱻ
ߵġ

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˲񾲵ݽĹ۵ϻ죬޴צ

ߣelse

Ҳ˵׺¡֤кݣֻǲҪ֤Ĺ۵㡣
漰Ⱦ˳˵硢ˮ֮ļԴҵú
̿ʯұ䡢ȡůͥʽ˵ȡƺͨһ
ı״źǣÿһĵ鶼ǳֹûš
̣ͥԼС¶õĻòҪȥ˵ȥ
顣ͷβǿŵȨҪͨʽǿ
ŵִǽżָļëر
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Ԫת򡱸 УѹУӦ

й326յ磨 أϤԪ26μɸ
ѧѧԺ֯ġŴáΪŪת򡱵ݽ
һϢ縴ѧУѱʾǿҲѧУû
ؽڵԪбۡ

ΪѧѧѧԺŴ92˶ʿҵ½ƼУ
΢ȺϢ̱ʾѧΪѧѧ֮
һתУĿѧռӰԲ㡱Ϊǿ
ҽУӦμӸûѧоרҵԱѧӦ
е

ѧѧѧԺԹڻӦʱʾԪɣ
ѧԺɣѧԺ쵼ǲ
ת򣩵ıġ

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ûҪϲȡʩ

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غϼ292015.03.16-20


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־ ?@BobDeng2  Mar 16 
@fangshimin ССʽSUVûд

 @fangshimin    Mar 16
д209,098
http://www.dieselforum.org/index.cfm?objectid=F6F41D00-400E-11E3-833F0
00C296BA163&mode=detail&fips=06  ȱ20@BobDeng2: 
@fangshimin ССʽSUVûд

 @fangshimin    Mar 17
202007ԺͺŴʣµ20пʽҲ
ⷽݡˡ@BobDeng2

 @fangshimin    Mar 16
񾲣ݣȫ귢ؿͳ鴫Ʊ29913ս᰸3281
ʵȫ29913·죨inspection3281ŷcitation
˭ģѵʹԪһ룿 
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 @fangshimin    Mar 16
񾲳ʾ׶ؿȾŨȣעƪġʵͼ
ڶƪĵͼһƪĶоģ׶غ޹ϵʵ
ԴǴеıUrban China(p.453)ֻñ滹ᵽ
 
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 @fangshimin    Mar 17
ҽٶˣ޴ΪͲ٣ԴΪ
ϴأҽ 
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Wayson He ?@WaysonHe  Mar 17 
@fangshimin Ȼѷһ΢һƬӵͬȻһ΢ϵһ
ԱƬгֵڶݲᲢۡýİѴϢ
󣬶νǵĵӾͲҪˡ

 @fangshimin    Mar 17
Լ¼Ƭı׼ҷÿһ΢ǶҵĹά@WaysonHe: 
@fangshimin Ȼѷһ΢һƬӵͬȻһ΢ϵһ
ԱƬгֵڶݲᲢۡýİѴϢ
󣬶νǵĵӾͲҪˡ

 @fangshimin    Mar 17
ͼ˾˵ժҥӱժȡ١Ƿ
̷ժȡ١ 
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 @fangshimin    Mar 17
̨廷ʿ˵硢ˮ硢硢硢̫ܷ磬
Ҫõ磬Ƿˡð硱̫ΰˣԴ⳹׽
ˡ 
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 @fangshimin    Mar 17
˫Դӱν¶Ӣģˣ´θɴû
ˡ 
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 @fangshimin    Mar 17
Щϲ˵᷽ӣǡҲϲ˾ϣǡ
˭ںϲϲƵģʲôѽֲš
https://pbs.twimg.com/media/CAV9BoPVIAAwUnA.jpg:large

һ ?@cngdgz  Mar 17 
2015317 @ѼAudrey @¹_George Ȩװͥ´ӻ
ͥȱϯʦ˵ڱɷ޷ͥ315ڹ
Ժ@é ġŮ١⼸317һֱڹݻ
Ϊýˣӷͥѵˣ

 @fangshimin    Mar 17
Ѽҥ쵽Լͷϡ@cngdgz: 2015317ѼѺͳ¹Ȩװ
ͥ´ӻͥȱϯʦ˵ڱɷ޷ͥ315
ڹݴԺéΡŮ١⼸317һֱ
ڹݻΪýˣӷͥѵ

 @fangshimin    Mar 17
ԭ̲ĶӢĵʦ˵˫ؼ尾ܴݲУŲ
ʼ߶߶ײ 
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 @fangshimin    Mar 17
90롱315ؼ | ĲݣĪѳʬ
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 @fangshimin    Mar 17
·1000Сѧζ1000Ľ
ϵһлĲƸô˵Сѧȫ
ϵһ 
https://pbs.twimg.com/media/CAWatKcU0AEEGuI.jpg:large

 @fangshimin    Mar 17
ϼ 
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 @fangshimin    Mar 17
ӡڼѧĽƭϻ誣Ҫء 
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 @fangshimin    Mar 17
Ƶлʣø˭@cngdgz: @ѼAudrey Ƶл
ݺͱ˵317ڱɷ315ͱĻ޷ϯ@¹_George 
װͥҾֱӳʾľǻЧܻá 
https://pbs.twimg.com/media/CAWfSmbU8AAHcNY.jpg:large

 @fangshimin    Mar 17
ƵĿFMר47ڡҪҪѧ
http://v2.kaolafm.com/MZ_APP_PROVIDERS/redirectAddress.do?channel=1480&classId=429&columnId=321&programId=86560&fileSize=2900156&audioUrl=/mz/audios/201503/d2cbd697-6614-417d-bebc-cd56729af507.mp3 

 retweeted
 wELLxin @wellxin    Mar 17
ѧTTȺһ׷ͼͼݡлӵĿգл
OSAICĳ飬лȺ֧ߵİģȺܹ$1836.55ͬʱ
ϵ10ͼݽжĿǰͼյͼ鲢ϼܡ@zixian 
https://pbs.twimg.com/media/CAV7cLwUsAIoIrU.png
https://pbs.twimg.com/media/CAV7chSUYAART4f.png

 @fangshimin    Mar 18
19962014ת󶹡޻ֲٷֱȡ 
https://pbs.twimg.com/media/CAXgNz9UYAEPTJ-.jpg:large

ɽ֮ ?@shandaozhijian  Mar 18 
@fangshimin 

 @fangshimin    Mar 18
½òŶͻϳһһֱߡ
@shandaozhijian: @fangshimin ӡ

ں ?@intronintron  Mar 18 
@fangshimin @shandaozhijian ԪŶϳ½ֱߡ

 @fangshimin    Mar 18
иĸСѧЩǸߡ@intronintron: @fangshimin 
@shandaozhijian ԪŶϳ½ֱߡ

 @fangshimin    Mar 18
ճʱ򣬲μѵͬѧиͻ˹̹ˣй˾͸
һ˵ϲƹˮƽ˵ҲУҲƽˮƽ
˵ǹҵƹƽˮƽԴҵˡʲôй
ǡ˻ΪȨйء

 @fangshimin    Mar 18
ҲǸСĿ򡢰򡢱ȫû
ȣҲû°ƶƻѧʡ
йš

 @fangshimin    Mar 18
ƹƹݹŴۻڵػھ֮
˶ʺйƹص㣬ΪëϲƹԾٹ¾ͶҪ
СʱûŰڽͷƶСڽͷ
򣬸ƹʲôϵΪܰ쵽Ҳһܰ쵽

 @fangshimin    Mar 18
Ǹѧģ@cngdgz: @ѼAudrey ɾԼ316賿֤ʵ
315ڹݴԺϷ΢ΪͿ֤317ͥ첻ڹݣ 

https://pbs.twimg.com/media/CAW0WMQUwAEWD0M.jpg:large

 @fangshimin    Mar 18
90롱315ؼ | ٰƭ
http://mp.weixin.qq.com/s?__biz=MzAxNzIxMjM0NQ==&mid=208184790&idx=1&sn=d949735d51fd471b6c7232c110c333dd#rd 

 @fangshimin    Mar 18
дӰҹоˮԣ˵ôӲˮЬ
ôúһþˡʵӢǲЬĲˮЬ⣬
ҹȻ̣ƽǸֻȢҳԱ壬Ȣ
Ů㲻ŵԵġӰʵᵽ㣬̫ҵ

 @fangshimin    Mar 18
Ҽұʱҹͷ⣬ΪʲôЬûҹʧ
Ӱ˫Ьǰˡ

 @fangshimin    Mar 18
ͳͯһЩֵڿȻ⣬Ϊȷ
ͯڵ߸ԭѩӻ⺷˯Ǻˣ
ӱǿҹ˾ȵʵԭϴĸıԭ
˺衣ԭŮǱġ

jilannnnnn ?@jilan94  Mar 18 
@fangshimin ĩȥˡҹȻ6Ůһס
Ҫߣȴúܺÿ汾Ѿ鸴ӻͺˣЩеıС
ҲⲻˡҲӽǿҵԪأǵȷ
̴ӹǸˣǸĿأ

 @fangshimin    Mar 18
͵ŷ޴ӱǹӶ˵ǿܵģ޾Ǹˡ@jilan94

 @fangshimin    Mar 18
ҪǻģӰӵĻ顢õʱ䳤̡
ȵν޹أĿǰֻͯڻʱ䳤йأڻ
ʱԽʹڻ⿴鿴ĻӷԽͣԭǿ̼
Ͱķڷֹ
http://www.nature.com/news/the-myopia-boom-1.17120?WT.mc_id=TWT_NatureNews 

Fei Yang ?@feiyangvr  Mar 18 
@fangshimin ǼԽô£˵޹ϵ

 @fangshimin    Mar 18
Խӡйҽġ@feiyangvr: @fangshimin ǼԽ
ô£˵޹ϵ

 @fangshimin    Mar 19
ʵΪǸѧ̩ġ¹ٵԭʼɷģ
вϣ类ֽ¶ˣûѧ̩ʲô¡ 
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 @fangshimin    Mar 19
2005ƽһйһ152012ƽһйһ22
20йΰʻֱ 
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к ?@yunxianhs  Mar 19 
@fangshimin ˿ڣֲ??

 @fangshimin    Mar 19
ԭͼԭʼָйһ2012йΪ
Ĺң2.81ˣԼռ˿ڵ֮һ@yunxianhs: 
@fangshimin ˿ڣֲ??

 @fangshimin    Mar 19
ĶûУӢˮƽ̫ܰŦ˼ǰν
˹Ħ˵ɹµǰоͷȴţ
ÿһʱ԰֪ͶԶһ㡣
https://pbs.twimg.com/media/CActFtjUcAEkBnv.jpg:large

 @fangshimin    Mar 19
Ϊ˸У԰ͣƣ򽫳ΪйѧΨһ
Ŀˡ 
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 @fangshimin    Mar 19
ӡȸĸ˷߱ðΣհμͳŮס֪ǲһ
ӡȵĽƶȣ 
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 @fangshimin    Mar 19
ƻ200ҺмСѧɫѧУƻɫѧ
У550-650ս1000ɫѧУһһǣ
Ӣָտɴ

 @fangshimin    Mar 19
˵ġٽӡָ۹ȡ˻½״ʱ
ģ͵Խ޹صһּ͹ҽ˵ֲξ
ɡԽӡġԽӡ¡һǲģ
ԽԽֱԼֹͣŽһʼǿġԽӡ

 @fangshimin    Mar 19
90롱315ؼ | Чõġơ
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 ?@zixian  Mar 19 
ѧ߿꡶񷶥֮¡һ̵ķȾĻ˽֪Ķ
⡣жŵ˵¹һһ˶γ
ʶĻԡ򿪸ɣֱΪ̡ԭø
Ƿ
http://www.nytimes.com/2015/03/19/opinion/why-under-the-dome-found-a-ready-audience-in-china.html 

 @fangshimin    Mar 19
й㻷ĺܶ಻Ϊ˻Ρ@zixian: ѧ߿꡶񷶥֮
¡һ̵ķȾĻ˽֪Ķ⡣
жŵ˵¹һһ˶γɹʶĻԡ
ɣֱΪ̡ԭøǷ

 @fangshimin    Mar 19
²¡ٳĲ񾲡񷶥֮¡http://qr.ae/QhcLd  
http://fangzhouzi.tumblr.com/post/114107974090 

 @fangshimin    Mar 19
ٳĲ񾲡񷶥֮¡һıQuoraɾˣ˵spamԺ
QuoraģķMediumhttp://t.cn/RAhByFL 

jinqiao ?@jinqiao511  Mar 19 
Quaraûôװ@fangshimin: ٳĲ񾲡񷶥֮¡һ
ıQuoraɾˣ˵spamԺQuoraģķMedium
http://t.cn/RAhByFL 

 @fangshimin    Mar 19
˵ҰվspamָӡҲ
﷢ĵǱǽϴƵǴȥһûɾ
վǣһһҾˡ@jinqiao511: Quaraûôװ

 @fangshimin    Mar 20
ӪƸαѧ治٣һҽһҽ 
https://pbs.twimg.com/media/CAheVj5UgAEWaDo.jpg:large

 @fangshimin    Mar 20
㽶ǷܻأҽĻشû˵ϡ
http://mp.weixin.qq.com/s?__biz=MzAxNzIxMjM0NQ==&mid=208158593&idx=2&sn=c15d888555c211664a2a808bc2b0479b#rd  
ҽ֮Ϊ㽶ͨ
㣬̬롣ʵϲ㽶Ϊн϶ĵۺͽʣ
ء

 @fangshimin    Mar 20
ڵܿ𣿡ٳĲ񾲡񷶥֮¡
http://t.cn/RAhByFL 

 @fangshimin    Mar 20
Evernoteܿ𣿡ٳĲ񾲡񷶥֮¡
https://www.evernote.com/shard/s546/sh/c96900b0-845c-426c-8ac9-006335192b0a/3679a1107bb2b8ca295719bfa47f1f7e 

 @fangshimin    Mar 20
˵ԪڶӵĽĿ̫ʷʱͣˣϧԺ
ｲʮˡ

 @fangshimin    Mar 20
82289339ˣȻʮָۡ 
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 @fangshimin    Mar 20
90롱315ؼ | Űġ߼ʡ
http://mp.weixin.qq.com/s?__biz=MzAxNzIxMjM0NQ==&mid=208251111&idx=1&sn=14102e69c00e0620721f3bf6e47ade99#rd 

 @fangshimin    Mar 20
˵ˣ΢¡ 
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 @fangshimin    Mar 20
һЩʦɼѾƳ˵Ѿ麬Ϊֵ25
Ѿ麬ֵʦõˮ׼ֵ10ppbȾƲ
ںˮÿ100Ѿƣ60꣬麬Ϊˮ׼5Ļ
ۻԼ100飬൱ڳ˼ƬţƽⶾƬ

 @fangshimin    Mar 20
𲻽תصҥԣŴԪ˾ϣҪѴԪһ
һͷӹȥ˾Ҫ䣬Ͳ˾ˡֻ
䣬ǾͷˡǲȥͳЦ⣬Э
ίԱҵҡ 
https://pbs.twimg.com/media/CAmFSo1UMAAIB5N.jpg:large

 @fangshimin    Mar 20
иоݵؽ¶˲ƵĴ٣ֻƿڴ
ԪһһӡҲҪҵҡˡ
https://pbs.twimg.com/media/CAmNb9PUUAAX97N.jpg:large

 ?@fybh6464  Mar 20 View translation
@fangshimin Ϸֻǽ¶٣˵ӦЩ˿ܻ
ʹûôص·ΰʲôģӳòӶԽͨԳ
ʶȶӰ죬Щ֧

 @fangshimin    Mar 20
һֻгĻ˻ı̬Щù
@fybh6464: @fangshimin Ϸֻǽ¶٣˵ӦЩ
˿ܻʹûôص·ΰʲôģӳòӶ
ͨԳʶȶӰ죬Щ֧

 @fangshimin    Mar 20
ڻûȵŮڣΪĨʱԵÿ͹ۣҳ
©ץס챻ɱ˳⡣ 
https://pbs.twimg.com/media/CAmT0F9VIAAQl73.jpg:large

 @fangshimin    Mar 20
ҪҵĲʿĵļ٣˵ҵİٷ֮ʮǳġܶ
ʮδҵҪֻгĻ̶ȡӢһ䲻Ҳ
ȲѧˡбΪ˸ȣ
ֱǹ塣 
https://pbs.twimg.com/media/CAmYUC1UkAA74Av.jpg:large

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